8ZCJ
Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSVfCLTVMSVDRYLaV |
| Chain | Residue | Details |
| G | THR125-VAL141 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| C | LEU70-SER84 | |
| C | ILE157-ILE171 | |
| C | LEU285-ALA299 | |
| C | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-hydroxyproline => ECO:0000269|PubMed:19584355 |
| Chain | Residue | Details |
| G | ALA379 | |
| B | ASN269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305 |
| Chain | Residue | Details |
| G | ASN-18 | |
| G | ASN-9 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 75 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| G | MET1-ALA38 | |
| G | ALA102-ARG113 | |
| G | ASP179-TRP197 | |
| G | VAL274-ALA283 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| G | ARG39-LEU66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 109 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| G | ARG67-ASN76 | |
| G | ASP136-LYS157 | |
| G | LEU223-THR247 | |
| G | ASP309-LEU364 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| G | ILE77-ALA101 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| G | LEU114-VAL135 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| G | LEU158-ALA178 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| G | GLY198-LEU222 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| G | ARG248-ALA273 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| G | GLY284-SER308 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000255 |
| Chain | Residue | Details |
| G | SER325 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine; by ZDHHC5 => ECO:0000250 |
| Chain | Residue | Details |
| G | CYS320 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| G | ASN13 | |
| G | ASN26 | |
| G | ASN187 |
