8SN8
 
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A) (class 6) | | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | 登録日 | 2023-04-26 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8SN9
 | | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 1) | | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | | 登録日 | 2023-04-26 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8OVJ
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8OVE
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8OVA
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8J1P
 | | Cryo-EM structure of Ufd4 in complex with K29/48 triUb | | 分子名称: | Ubiquitin, Ubiquitin fusion degradation protein 4 | | 著者 | Ai, H.S, Mao, J.X, Wu, X.W, Pan, M, Liu, L. | | 登録日 | 2023-04-13 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural Insights into the Molecular Mechanism of Ufd4-catalyzed Elongation of K48-linked Ubiquitin Chain through Lys29 Linkage
To Be Published
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8SH2
 | | KLHDC2 in complex with EloB and EloC | | 分子名称: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | | 著者 | Digianantonio, K.M, Bekes, M. | | 登録日 | 2023-04-13 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Nat.Struct.Mol.Biol., 31, 2024
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8J07
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8SEB
 | | Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | | 登録日 | 2023-04-08 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
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8SE9
 | | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2) | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | | 登録日 | 2023-04-08 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
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8SEA
 | | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1) | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | | 登録日 | 2023-04-08 | | 公開日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
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8SCB
 | | Terminating ribosome with SRI-41315 | | 分子名称: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | | 著者 | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | | 登録日 | 2023-04-05 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
Nat.Chem.Biol., 20, 2024
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8OO0
 | | Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S0, ... | | 著者 | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | 登録日 | 2023-04-04 | | 公開日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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8OL1
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8OKX
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8IVB
 | | K113-Ubiquitinated BAK | | 分子名称: | Bcl-2 homologous antagonist/killer, Ubiquitin | | 著者 | Dong, X, Cheng, P, Hou, Y.Z, Chen, Y.K, Liu, Z. | | 登録日 | 2023-03-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove.
Commun Biol, 6, 2023
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8OJ8
 | | 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | | 登録日 | 2023-03-24 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
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8OJ5
 | | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution) | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Penchev, I, DaRosa, P.A, Peter, J.J, Kulathu, Y, Becker, T, Beckmann, R, Kopito, R. | | 登録日 | 2023-03-23 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
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8OJ0
 | | 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native) | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | | 登録日 | 2023-03-23 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
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8ITP
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8GLP
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-03-22 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (1.67 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8OIF
 | | Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | | 著者 | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | | 登録日 | 2023-03-22 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.
Nat Commun, 14, 2023
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8OHD
 | | 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native) | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. | | 登録日 | 2023-03-21 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
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8OFF
 | | Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1) | | 分子名称: | BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ... | | 著者 | Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E. | | 登録日 | 2023-03-15 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes.
Nucleic Acids Res., 51, 2023
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8IPB
 | | Wheat 80S ribosome pausing on AUG-Stop with cycloheximide | | 分子名称: | 18S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 40S ribosomal protein eL8, ... | | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | | 登録日 | 2023-03-14 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Nat.Chem.Biol., 20, 2024
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