8SN9
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c with backside ubiquitin (UbcH5c chemically conjugated to histone H2A) (class 1)
Summary for 8SN9
Entry DOI | 10.2210/pdb8sn9/pdb |
EMDB information | 40617 |
Descriptor | Histone H3.1, ZINC ION, Histone H4, ... (10 entities in total) |
Functional Keywords | nucleosome core particle, chromatin, rnf168, ring domain, ubch5c, dna repair, dna double-strand break, homologous recombination, 53bp1, ubiquitin, structural protein-dna-transferase complex, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 13 |
Total formula weight | 238148.07 |
Authors | Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, G. (deposition date: 2023-04-26, release date: 2024-01-17, Last modification date: 2024-03-20) |
Primary citation | Hu, Q.,Zhao, D.,Cui, G.,Bhandari, J.,Thompson, J.R.,Botuyan, M.V.,Mer, G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84:839-853.e12, 2024 Cited by PubMed: 38242129DOI: 10.1016/j.molcel.2023.12.036 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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