8SEA
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1)
Summary for 8SEA
Entry DOI | 10.2210/pdb8sea/pdb |
EMDB information | 40407 40408 40409 40410 40782 40799 |
Descriptor | Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, Ubiquitin/ISG15-conjugating enzyme E2 L6, ... (4 entities in total) |
Functional Keywords | ligase, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 164107.97 |
Authors | |
Primary citation | Afsar, M.,Liu, G.,Jia, L.,Ruben, E.A.,Nayak, D.,Sayyad, Z.,Bury, P.D.S.,Cano, K.E.,Nayak, A.,Zhao, X.R.,Shukla, A.,Sung, P.,Wasmuth, E.V.,Gack, M.U.,Olsen, S.K. Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14:4786-4786, 2023 Cited by PubMed: 37553340DOI: 10.1038/s41467-023-39780-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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