8SH2

KLHDC2 in complex with EloB and EloC

Summary for 8SH2

• Entry DOI: 10.2210/pdb8sh2/pdb
• Related: 8sge 8sgf
• EMDB information: 40477
• Descriptor: Kelch domain-containing protein 2, Elongin-B, Elongin-C (3 entities in total)
• Functional Keywords: klhdc2, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 278004.91

Authors

Digianantonio, K.M.,Bekes, M. (deposition date: 2023-04-13, release date: 2024-01-03, Last modification date: 2024-02-28)

• Primary citation: Hickey, C.M.,Digianantonio, K.M.,Zimmermann, K.,Harbin, A.,Quinn, C.,Patel, A.,Gareiss, P.,Chapman, A.,Tiberi, B.,Dobrodziej, J.,Corradi, J.,Cacace, A.M.,Langley, D.R.,Bekes, M.; Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.; Nat.Struct.Mol.Biol., 31:311-322, 2024; PubMed: 38177675; DOI: 10.1038/s41594-023-01146-w

Experimental method

ELECTRON MICROSCOPY (3.74 Å)