8SH2

KLHDC2 in complex with EloB and EloC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0016567	biological_process	protein ubiquitination
A	0016604	cellular_component	nuclear body
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031965	cellular_component	nuclear membrane
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0016567	biological_process	protein ubiquitination
B	0016604	cellular_component	nuclear body
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031965	cellular_component	nuclear membrane
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0016567	biological_process	protein ubiquitination
C	0016604	cellular_component	nuclear body
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031965	cellular_component	nuclear membrane
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0016567	biological_process	protein ubiquitination
D	0016604	cellular_component	nuclear body
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031965	cellular_component	nuclear membrane
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0030891	cellular_component	VCB complex
E	0070449	cellular_component	elongin complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0030891	cellular_component	VCB complex
G	0070449	cellular_component	elongin complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0030891	cellular_component	VCB complex
I	0070449	cellular_component	elongin complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0030891	cellular_component	VCB complex
K	0070449	cellular_component	elongin complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Repeat: {"description":"Kelch 1","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	176
Details	Repeat: {"description":"Kelch 2","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	236
Details	Repeat: {"description":"Kelch 3","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	152
Details	Repeat: {"description":"Kelch 4","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	160
Details	Repeat: {"description":"Kelch 5","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	148
Details	Repeat: {"description":"Kelch 6","evidences":[{"source":"PubMed","id":"36805027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38177675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SH2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	260
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

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