PDB: 2832 件ウェブページステータス検索Chemie searchBIRD

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7O80	Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... 著者 Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. 登録日 2021-04-14 公開日 2021-06-02 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
7W5B	The cryo-EM structure of human C* complex 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... 著者 Zhan, X, Lu, Y, Shi, Y. 登録日 2021-11-29 公開日 2022-06-22 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5A	The cryo-EM structure of human pre-C*-II complex 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... 著者 Zhan, X, Lu, Y, Shi, Y. 登録日 2021-11-29 公開日 2022-06-22 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W59	The cryo-EM structure of human pre-C*-I complex 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... 著者 Zhan, X, Lu, Y, Shi, Y. 登録日 2021-11-29 公開日 2022-06-22 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
2CV0	Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu) and L-glutamate 分子名称: GLUTAMIC ACID, MAGNESIUM ION, glutamyl-tRNA synthetase, ... 著者 Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-31 公開日 2006-09-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase Structure, 14, 2006
2CV1	Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu), ATP, and an analog of L-glutamate: a quaternary complex 分子名称: (4S)-4-AMINO-5-HYDROXYPENTANOIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-31 公開日 2006-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu), ATP, and an analog of L-glutamate: a quaternary complex To be Published
2CV2	Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu) and an enzyme inhibitor, Glu-AMS 分子名称: CHLORIDE ION, MAGNESIUM ION, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE, ... 著者 Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-31 公開日 2006-09-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase Structure, 14, 2006
2DXI	2.2 A crystal structure of glutamyl-tRNA synthetase from Thermus thermophilus complexed with tRNA(Glu), ATP, and L-glutamol 分子名称: (4S)-4-AMINO-5-HYDROXYPENTANOIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Sekine, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-28 公開日 2006-10-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase Structure, 14, 2006
8CYI	Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide, ... 著者 Yadav, G.P, Wei, Z, Xiaozhi, Y, Chenglong, L, Jiang, Q. 登録日 2022-05-23 公開日 2023-04-12 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency. Commun Biol, 5, 2022
8CTB	Human PRMT5:MEP50 structure with Fragment 3 and MTA Bound 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, 7-chloro-1-methyl-1H-benzimidazol-2-amine, Methylosome protein 50, ... 著者 Gunn, R.J, Lawson, J.D, Smith, C.R. 登録日 2022-05-13 公開日 2022-10-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
3COJ	Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1 分子名称: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein 著者 Shen, Y, Tong, L. 登録日 2008-03-28 公開日 2008-05-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47, 2008
6ID0	Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... 著者 Zhang, X, Zhan, X, Yan, C, Shi, Y. 登録日 2018-09-07 公開日 2019-03-13 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
1AM4	COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS) 分子名称: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ... 著者 Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J. 登録日 1997-06-22 公開日 1998-07-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature, 388, 1997
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. 登録日 2019-09-26 公開日 2020-12-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
6UXY	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 分子名称: (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... 著者 Palte, R.L, Schneider, S.E. 登録日 2019-11-08 公開日 2020-08-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
8G1U	Structure of the methylosome-Lsm10/11 complex 分子名称: ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... 著者 Lin, M, Paige, A, Tong, L. 登録日 2023-02-03 公開日 2023-08-23 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
6UXX	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a 分子名称: (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Palte, R.L, Schneider, S.E. 登録日 2019-11-08 公開日 2020-08-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V0P	PRMT5 complex bound to covalent PBM inhibitor BRD6711 分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ... 著者 McMillan, B.J, McKinney, D.C. 登録日 2019-11-19 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
8OZ0	Structure of a human 48S translation initiation complex with eIF4F and eIF4A 分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Fraser, C.S, Ramakrishnan, V. 登録日 2023-05-06 公開日 2024-02-07 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A. Nat.Struct.Mol.Biol., 31, 2024
8PPK	Bat-Hp-CoV Nsp1 and eIF1 bound to the human 40S small ribosomal subunit 分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N. 登録日 2023-07-07 公開日 2023-10-18 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Universal features of Nsp1-mediated translational shutdown by coronaviruses. Mol.Cell, 83, 2023
1KOG	Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator 分子名称: 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase, Threonyl-tRNA synthetase mRNA, ... 著者 Torres-Larrios, A, Dock-Bregeon, A.C, Romby, P, Rees, B, Sankaranarayanan, R, Caillet, J, Springer, M, Ehresmann, C, Ehresmann, B, Moras, D. 登録日 2001-12-20 公開日 2002-04-26 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis of translational control by Escherichia coli threonyl tRNA synthetase. Nat.Struct.Biol., 9, 2002
5VYC	Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. 分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Lomakin, I.B, Stolboushkina, E.A, Vaidya, A.T, Garber, M.B, Dmitriev, S.E, Steitz, T.A. 登録日 2017-05-24 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1. Cell Rep, 20, 2017
6G5I	Cryo-EM structure of a late human pre-40S ribosomal subunit - State R 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2018-03-29 公開日 2018-06-06 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6G5H	Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2018-03-29 公開日 2018-06-06 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6G51	Cryo-EM structure of a late human pre-40S ribosomal subunit - State D 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. 登録日 2018-03-28 公開日 2018-06-06 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018

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