8CYI

Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5

Summary for 8CYI

Entry DOI	10.2210/pdb8cyi/pdb
EMDB information	27078
Descriptor	Protein arginine N-methyltransferase 5, Methylosome protein 50, N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide, ... (4 entities in total)
Functional Keywords	prmt5, protein arginine methyl transferase, mta-inhibitor synergy, cryo-em structure-based drug design, computational analysis, catalytic mechanism, drug discovery, docking analysis, oncoprotein, oncoprotein-transferase complex, oncoprotein/transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	106704.71
Authors	Yadav, G.P.,Wei, Z.,Xiaozhi, Y.,Chenglong, L.,Jiang, Q. (deposition date: 2022-05-23, release date: 2023-04-12)
Primary citation	Zhou, W.,Yadav, G.P.,Yang, X.,Qin, F.,Li, C.,Jiang, Q.X. Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency. Commun Biol, 5:1054-1054, 2022 Cited by PubMed: 36192627 DOI: 10.1038/s42003-022-03991-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.14 Å)

Structure validation