8CYI
Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein arginine N-methyltransferase 5 | polymer | 637 | 72766.7 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B (B) | Methylosome protein 50 | polymer | 309 | 33226.2 | 1 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | C (A) | N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide | non-polymer | 414.5 | 1 | Chemie (P2R) | |||
| 4 | D (A) | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 105992.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 711.8 | |
| All* | Total formula weight | 106704.7 |
