8CTB

Human PRMT5:MEP50 structure with Fragment 3 and MTA Bound

Summary for 8CTB

Entry DOI	10.2210/pdb8ctb/pdb
Descriptor	Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-chloro-1-methyl-1H-benzimidazol-2-amine, ... (5 entities in total)
Functional Keywords	mtap, methyl transferase, fragment-based lead discovery, fbdd, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	112104.99
Authors	Gunn, R.J.,Lawson, J.D.,Smith, C.R. (deposition date: 2022-05-13, release date: 2022-10-05, Last modification date: 2023-10-25)
Primary citation	Smith, C.R.,Kulyk, S.,Ahmad, M.U.D.,Arkhipova, V.,Christensen, J.G.,Gunn, R.J.,Ivetac, A.,Ketcham, J.M.,Kuehler, J.,Lawson, J.D.,Thomas, N.C.,Wang, X.,Marx, M.A. Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13:1549-1564, 2022 Cited by PubMed: 36545438 DOI: 10.1039/d2md00163b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation