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2B3O
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Crystal structure of human tyrosine phosphatase SHP-1
分子名称: Tyrosine-protein phosphatase, non-receptor type 6
著者Yang, J, Liu, L, He, D, Song, X, Liang, X, Zhao, Z.J, Zhou, G.W.
登録日2005-09-20
公開日2005-10-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 278, 2003
2AUG
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Crystal structure of the Grb14 SH2 domain
分子名称: Growth factor receptor-bound protein 14
著者Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R.
登録日2005-08-27
公開日2005-11-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Mol.Cell, 20, 2005
1X6C
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Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1
分子名称: Tyrosine-protein phosphatase, non-receptor type 6
著者Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-17
公開日2005-11-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1
To be Published
2CR4
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Solution structure of the SH2 domain of human SH3BP2 protein
分子名称: SH3 domain-binding protein 2
著者Hatta, R, Tomizawa, T, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-20
公開日2005-11-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain of human SH3BP2 protein
To be Published
2CS0
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BU of 2cs0 by Molmil
Solution structure of the SH2 domain of human HSH2D protein
分子名称: Hematopoietic SH2 domain containing
著者Kurosaki, C, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-20
公開日2005-11-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain of human HSH2D protein
To be published
2CRH
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Solution structure of the SH2 domain of human proto-oncogene protein VAV1
分子名称: Vav proto-oncogene
著者Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-20
公開日2005-11-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain of human proto-oncogene protein VAV1
to be published
2FCI
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BU of 2fci by Molmil
Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
分子名称: C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350
著者Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B.
登録日2005-12-12
公開日2006-01-31
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase
J.Mol.Biol., 356, 2006
1X27
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Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
分子名称: CRK-associated substrate, Proto-oncogene tyrosine-protein kinase LCK, SODIUM ION
著者Nasertorabi, F, Tars, K, Becherer, K, Kodandapani, R, Liljas, L, Vuori, K, Ely, K.R.
登録日2005-04-20
公開日2006-02-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis for regulation of Src by the docking protein p130Cas
J.MOL.RECOG., 19, 2006
2ETZ
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The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide
分子名称: Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK
著者Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H.
登録日2005-10-27
公開日2006-02-07
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.
J.Mol.Biol., 357, 2006
2EU0
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The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide
分子名称: Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK
著者Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H.
登録日2005-10-27
公開日2006-02-07
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.
J.Mol.Biol., 357, 2006
2C9W
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CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
分子名称: NICKEL (II) ION, SULFATE ION, SUPPRESSOR OF CYTOKINE SIGNALING 2, ...
著者Debreczeni, J.E, Bullock, A, Amos, A, Savitsky, P, Barr, A, Burgess, N, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S.
登録日2005-12-14
公開日2006-02-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
2FO0
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Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
著者Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J.
登録日2006-01-12
公開日2006-03-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21, 2006
2CIA
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human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOPLASMIC PROTEIN NCK2, ISOPROPYL ALCOHOL, ...
著者Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W.
登録日2006-03-17
公開日2006-04-24
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains.
J.Biol.Chem., 281, 2006
2CI8
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sh2 domain of human nck1 adaptor protein - uncomplexed
分子名称: CYTOPLASMIC PROTEIN NCK1, PENTAETHYLENE GLYCOL, SULFATE ION
著者Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W.
登録日2006-03-17
公開日2006-04-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains.
J.Biol.Chem., 281, 2006
2CI9
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Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir
分子名称: CYTOPLASMIC PROTEIN NCK1, TRANSLOCATED INTIMIN RECEPTOR
著者Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W.
登録日2006-03-17
公開日2006-04-24
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains.
J.Biol.Chem., 281, 2006
2BBU
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solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor
分子名称: GP130 PHOSPHOPEPTIDE, Suppressor of cytokine signaling 3
著者Babon, J.J, Yao, S, Norton, R.S.
登録日2005-10-17
公開日2006-05-02
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability
Mol.Cell, 22, 2006
2IUG
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain
分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide
分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2021-04-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUH
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide
分子名称: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2021-04-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2H46
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Native domain-swapped dimer crystal structure of the Grb2 SH2 domain
分子名称: GLYCEROL, Growth Receptor Binding Protein 2
著者Benfield, A.P, Martin, S.F, Whiddon, B.B.
登録日2006-05-23
公開日2006-06-06
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2IZV
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CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ...
著者Debreczeni, J.E, Bullock, A, Papagrigoriou, E, Turnbull, A, Pike, A.C.W, Gorrec, F, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S.
登録日2006-07-26
公開日2006-08-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Structure, 15, 2007
2HDV
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Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
分子名称: SH2-B PH domain containing signaling mediator 1 gamma isoform
著者Hu, J, Hubbard, S.R.
登録日2006-06-20
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HDX
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Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
分子名称: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform
著者Hu, J, Hubbard, S.R.
登録日2006-06-21
公開日2006-08-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2H5K
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Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
分子名称: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand
著者Benfield, A.P, Whiddon, B.B, Martin, S.F.
登録日2006-05-26
公開日2006-08-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2HUW
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X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION
著者Benfield, A.P, Martin, S.F.
登録日2006-07-27
公開日2006-08-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45, 2006

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