The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide

Summary for 2ETZ

Related1LUI 1LUK 1LUM 1LUN 2EU0
DescriptorTyrosine-protein kinase ITK/TSK, Lymphocyte cytosolic protein 2 phosphopeptide fragment (2 entities in total)
Functional Keywordscis/trans isomerization, interleukin-2 tyrosine kinase, itk, t-cell specific kinase, tsk, src homology 2, sh2, proline, phosphotyrosine binding, transferase
Biological sourceMus musculus (house mouse)
Cellular locationCell membrane Q03526
Cytoplasm (Probable) Q60787
Total number of polymer chains2
Total molecular weight13354.97
Sundd, M.,Pletneva, E.V.,Fulton, D.B.,Andreotti, A.H. (deposition date: 2005-10-27, release date: 2006-02-07, Last modification date: 2011-07-13)
Primary citation
Pletneva, E.V.,Sundd, M.,Fulton, D.B.,Andreotti, A.H.
Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.
J.Mol.Biol., 357:550-561, 2006
PubMed: 16436281 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2005.12.073
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers30718.8%47.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures