2ETZ

The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide

Summary for 2ETZ

Related1LUI 1LUK 1LUM 1LUN 2EU0
DescriptorTyrosine-protein kinase ITK/TSK, Lymphocyte cytosolic protein 2 phosphopeptide fragment (2 entities in total)
Functional Keywordscis/trans isomerization, interleukin-2 tyrosine kinase, itk, t-cell specific kinase, tsk, src homology 2, sh2, proline, phosphotyrosine binding, transferase
Biological sourceMus musculus (house mouse)
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Cellular locationCell membrane Q03526
Cytoplasm (Probable) Q60787
Total number of polymer chains2
Total molecular weight13354.97
Authors
Sundd, M.,Pletneva, E.V.,Fulton, D.B.,Andreotti, A.H. (deposition date: 2005-10-27, release date: 2006-02-07, Last modification date: 2011-07-13)
Primary citation
Pletneva, E.V.,Sundd, M.,Fulton, D.B.,Andreotti, A.H.
Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.
J.Mol.Biol., 357:550-561, 2006
PubMed: 16436281 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2005.12.073
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers30718.8%47.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures