2FO0

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Summary for 2FO0

DescriptorProto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM), MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ... (5 entities in total)
Functional Keywordsn-terminal cap, autoinhibition, myristoylation, sh3-sh2 clamp, phosphoserine, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight57292.21
Authors
Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2006-01-12, release date: 2006-03-21, Last modification date: 2017-08-02)
Primary citation
Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J.
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21:787-798, 2006
PubMed: 16543148 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2006.01.035
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.27 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24570.2%2.7%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2fo0
no rotation
Molmil generated image of 2fo0
rotated about x axis by 90°
Molmil generated image of 2fo0
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2018 Protein Data Bank Japan