2FO0

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MYR A 701

Chain	Residue
A	GLU481
A	ILE521

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE P16 A 702

Chain	Residue
A	GLU335
A	PHE336
A	MET337
A	GLY340
A	LEU389
A	ALA399
A	ASP400
A	TYR272
A	VAL275
A	ALA288
A	LYS290
A	GLU305
A	MET309
A	THR334

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 703

Chain	Residue
A	TYR345
A	GLY391
A	GLU392
A	ASN393
A	HIS394

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 704

Chain	Residue
A	THR197
A	ALA198
A	THR296
A	MET297

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK

Chain	Residue	Details
A	LEU267-LYS290

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASN382

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	LYS290
A	GLU335
A	LEU267

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16543148, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SEP69

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16912036, ECO:0000269|PubMed:18775435

Chain	Residue	Details
A	TYR89

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:16912036

Chain	Residue	Details
A	TYR147
A	TYR158
A	TYR191
A	TYR204
A	TYR234
A	TYR134

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16912036

Chain	Residue	Details
A	TYR245

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42684

Chain	Residue	Details
A	SER248

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	TYR276
A	TYR432
A	TYR272

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036

Chain	Residue	Details
A	TYR412

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00520

Chain	Residue	Details
A	SER465

---