2FO0
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM) | polymer | 495 | 56452.4 | 1 | UniProt (P00519-2) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) UniProt (by SIFTS) (P00519) In PDB | Homo sapiens (human) | |
| 2 | A | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 3 | A | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 427.3 | 1 | Chemie (P16) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A: 1 - 14 (UniProt: P00519-2)
A: 57 - 531 (UniProt: P00519-2)
| PDB | External Database | Details |
|---|---|---|
| Glu 532 | - | cloning artifact |
| Asn 533 | - | cloning artifact |
| Leu 534 | - | cloning artifact |
| Tyr 535 | - | cloning artifact |
| Gly 536 | - | cloning artifact |
| Gln 537 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Sep 69 | Ser 69 | modified residue |
| Asn 382 | Asp 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56452.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 839.8 | |
| All* | Total formula weight | 57292.2 |
