2HDX

Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

Summary for 2HDX

DescriptorSH2-B PH domain containing signaling mediator 1 gamma isoform, Jak2 protein (3 entities in total)
Functional Keywordssh2, jak2, phosphotyrosine, adapter protein, signaling protein
Biological sourceMus musculus (house mouse)
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Total number of polymer chains12
Total molecular weight81991.82
Authors
Hu, J.,Hubbard, S.R. (deposition date: 2006-06-21, release date: 2006-08-08, Last modification date: 2011-07-13)
Primary citation
Hu, J.,Hubbard, S.R.
Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361:69-79, 2006
PubMed: 16824542 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.05.070
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23910 1.1% 2.1% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25