Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

Summary for 2HDX

DescriptorSH2-B PH domain containing signaling mediator 1 gamma isoform, Jak2 protein (3 entities in total)
Functional Keywordssh2, jak2, phosphotyrosine, adapter protein, signaling protein
Biological sourceMus musculus (house mouse)
Total number of polymer chains12
Total molecular weight81991.82
Hu, J.,Hubbard, S.R. (deposition date: 2006-06-21, release date: 2006-08-08, Last modification date: 2011-07-13)
Primary citation
Hu, J.,Hubbard, S.R.
Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361:69-79, 2006
PubMed: 16824542 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.05.070
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23910 1.1% 2.1% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25