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2HDX

Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...SH2-B PH domain containing signaling mediator 1 gamma isoformpolymer11112276.06UniProt (Q9WVM5)
Pfam (PF00017)
UniProt (by SIFTS) (Q91ZM2)
In PDB
Mus musculus (house mouse)
2G, H, I, J, K...Jak2 proteinpolymer111389.36UniProt (Q7TQD0)
UniProt (by SIFTS) (Q62120)
In PDB
3waterwater18.0320Chemie (HOH)
Sequence modifications
A, B, C, D, E, F: 519 - 627 (UniProt: Q9WVM5)
PDBExternal DatabaseDetails
Gly 517-cloning artifact
Ser 518-cloning artifact
Ala 583Glu 563engineered mutation
Ala 584Glu 564engineered mutation
His 593Trp 573engineered mutation
G, H, I, J, K, L: 810 - 820 (UniProt: Q7TQD0)
PDBExternal DatabaseDetails
Ptr 813Tyr 813modified residue
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight81991.8
All*Total formula weight81991.8
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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