2HDX

Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	SH2-B PH domain containing signaling mediator 1 gamma isoform	polymer	111	12276.0	6	UniProt (Q9WVM5) Pfam (PF00017) UniProt (by SIFTS) (Q91ZM2)	Mus musculus (house mouse)
2	G, H, I, J, K... (G, H, I, J, K...)	Jak2 protein	polymer	11	1389.3	6	UniProt (Q7TQD0) UniProt (by SIFTS) (Q62120)
3	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 519 - 627 (UniProt: Q9WVM5)

PDB	External Database	Details
Gly 517	-	cloning artifact
Ser 518	-	cloning artifact
Ala 583	Glu 563	engineered mutation
Ala 584	Glu 564	engineered mutation
His 593	Trp 573	engineered mutation

G, H, I, J, K, L: 810 - 820 (UniProt: Q7TQD0)

PDB	External Database	Details
Ptr 813	Tyr 813	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	81991.8
All*	Total formula weight	81991.8

*Water molecules are not included.