2HDX
Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | SH2-B PH domain containing signaling mediator 1 gamma isoform | polymer | 111 | 12276.0 | 6 | UniProt (Q9WVM5) Pfam (PF00017) UniProt (by SIFTS) (Q91ZM2) In PDB | Mus musculus (house mouse) | |
2 | G, H, I, J, K... | Jak2 protein | polymer | 11 | 1389.3 | 6 | UniProt (Q7TQD0) UniProt (by SIFTS) (Q62120) In PDB | ||
3 | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 519 - 627 (UniProt: Q9WVM5)
G, H, I, J, K, L: 810 - 820 (UniProt: Q7TQD0)
PDB | External Database | Details |
---|---|---|
Gly 517 | - | cloning artifact |
Ser 518 | - | cloning artifact |
Ala 583 | Glu 563 | engineered mutation |
Ala 584 | Glu 564 | engineered mutation |
His 593 | Trp 573 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ptr 813 | Tyr 813 | modified residue |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 81991.8 | |
All* | Total formula weight | 81991.8 |