PDB: 595 件ウェブページステータス検索Chemie searchBIRD

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2KNO	NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) 分子名称: Tensin-like C1 domain-containing phosphatase 著者 Chen, L, Feng, R, Liu, C, Zhu, G. 登録日 2009-08-27 公開日 2010-09-01 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) To be Published
2H46	Native domain-swapped dimer crystal structure of the Grb2 SH2 domain 分子名称: GLYCEROL, Growth Receptor Binding Protein 2 著者 Benfield, A.P, Martin, S.F, Whiddon, B.B. 登録日 2006-05-23 公開日 2006-06-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2HDV	Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B 分子名称: SH2-B PH domain containing signaling mediator 1 gamma isoform 著者 Hu, J, Hubbard, S.R. 登録日 2006-06-20 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2HDX	Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide 分子名称: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform 著者 Hu, J, Hubbard, S.R. 登録日 2006-06-21 公開日 2006-08-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2H5K	Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2 分子名称: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand 著者 Benfield, A.P, Whiddon, B.B, Martin, S.F. 登録日 2006-05-26 公開日 2006-08-15 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2GSB	Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 分子名称: Ras GTPase-activating protein 1 著者 Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-26 公開日 2007-05-01 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 To be Published
2L6K	Solution Structure of a Nonphosphorylated Peptide Recognizing Domain 分子名称: Tensin-like C1 domain-containing phosphatase 著者 Dai, K, Liao, S, Zhang, J, Zhang, X, Tu, X. 登録日 2010-11-22 公開日 2011-10-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1 Plos One, 6, 2011
1I3Z	MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE 分子名称: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE 著者 Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. 登録日 2001-02-19 公開日 2003-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Eur.J.Biochem., 20, 2001
2LNW	Identification and structural basis for a novel interaction between Vav2 and Arap3 分子名称: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 著者 Wu, B, Zhang, J, Wu, J, Shi, Y. 登録日 2012-01-05 公開日 2012-11-21 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
2LCT	Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide 分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK 著者 Chen, C, Gorenstein, N, Post, C. 登録日 2011-05-09 公開日 2011-06-01 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol.Cell.Biol., 31, 2011
2LNX	Solution structure of Vav2 SH2 domain 分子名称: Guanine nucleotide exchange factor VAV2 著者 Wu, B, Zhang, J, Wu, J, Shi, Y. 登録日 2012-01-05 公開日 2012-11-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor 分子名称: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC 著者 Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. 登録日 2001-11-02 公開日 2002-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1IJR	Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic 分子名称: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK 著者 Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. 登録日 2001-04-27 公開日 2002-05-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
2MK2	Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 著者 Yang, Y, Ramelot, T.A, Janjua, H, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) 登録日 2014-01-23 公開日 2014-03-05 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A. To be Published
2MC1	Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide 分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK 著者 Chen, C, Piraner, D, Gorenstein, N.M, Geahlen, R.L, Post, C.B. 登録日 2013-08-13 公開日 2013-08-28 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain. Biopolymers, 99, 2013
1KA7	SAP/SH2D1A bound to peptide n-Y-c 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide 分子名称: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase 著者 Lubman, O.Y, Waksman, G. 登録日 2001-11-07 公開日 2002-04-17 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-pY 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
2MRJ	Structure of Fyn protein SH2 bound 分子名称: Tyrosine-protein kinase Fyn 著者 Huculeci, R, Buts, L, Lenaerts, T, Van Nuland, N. 登録日 2014-07-09 公開日 2015-07-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK 分子名称: Csk Homologous Kinase 著者 Murthy, T.V.S, Webster, G.D. 登録日 2001-09-04 公開日 2001-09-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL 分子名称: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL 著者 Eck, M, Harrison, S. 登録日 1994-12-12 公開日 1995-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1JYU	Xray Structure of Grb2 SH2 Domain 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
2MRK	Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide 分子名称: C-terminal Tyrosine-protein kinase Fyn, Tyrosine-protein kinase Fyn 著者 Huculeci, R, Buts, L, Lenaerts, A.J, van Nuland, N. 登録日 2014-07-09 公開日 2015-07-15 最終更新日 2016-12-14 実験手法 SOLUTION NMR 主引用文献 Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002

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