2MRK
Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide
Summary for 2MRK
Entry DOI | 10.2210/pdb2mrk/pdb |
Related | 2mqi 2mrj |
NMR Information | BMRB: 25082 |
Descriptor | Tyrosine-protein kinase Fyn, C-terminal Tyrosine-protein kinase Fyn (2 entities in total) |
Functional Keywords | phosphorylated peptide, fyn kinase, sh2 domain, src kinase, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P06241 P06241 |
Total number of polymer chains | 2 |
Total formula weight | 12944.54 |
Authors | Huculeci, R.,Buts, L.,Lenaerts, A.J.,van Nuland, N. (deposition date: 2014-07-09, release date: 2015-07-15, Last modification date: 2016-12-14) |
Primary citation | Huculeci, R.,Cilia, E.,Lyczek, A.,Buts, L.,Houben, K.,Seeliger, M.A.,van Nuland, N.,Lenaerts, T. Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24:1947-1959, 2016 Cited by PubMed: 27692963DOI: 10.1016/j.str.2016.08.016 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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