2LCT

Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide

Summary for 2LCT

• Entry DOI: 10.2210/pdb2lct/pdb
• NMR Information: BMRB: 17632
• Descriptor: Proto-oncogene vav, Tyrosine-protein kinase SYK (2 entities in total)
• Functional Keywords: phosphopeptide, syk kinase, tyrosine kinase, protein-peptide complex, phosphorylated peptide, phosphotyrosine binding domain, b cell signaling protein, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane (Probable): P48025
• Total number of polymer chains: 2
• Total formula weight: 14009.60

Authors

Chen, C.,Gorenstein, N.,Post, C. (deposition date: 2011-05-09, release date: 2011-06-01, Last modification date: 2023-06-14)

• Primary citation: Chen, C.H.,Martin, V.A.,Gorenstein, N.M.,Geahlen, R.L.,Post, C.B.; Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.; Mol.Cell.Biol., 31:2984-2996, 2011; PubMed: 21606197; DOI: 10.1128/MCB.05043-11

Experimental method

SOLUTION NMR