3VUQ
| Crystal structure of TTHA0167, a transcriptional regulator, TetR/AcrR family from Thermus thermophilus HB8 | 分子名称: | Transcriptional regulator (TetR/AcrR family) | 著者 | Agari, Y, Sakamoto, K, Agari, K, Kuramitsu, S, Shinkai, A. | 登録日 | 2012-07-04 | 公開日 | 2013-02-27 | 最終更新日 | 2013-12-25 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure and function of a TetR family transcriptional regulator, SbtR, from thermus thermophilus HB8 Proteins, 81, 2013
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4FX0
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6QJX
| TetR(D) T103A mutant in complex with minocycline and magnesium | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | 登録日 | 2019-01-27 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
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3MVB
| Crystal structure of a triple RFY mutant of human MTERF1 bound to the termination sequence | 分子名称: | 5'-D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)-3', 5'-D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)-3', Transcription termination factor, ... | 著者 | Yakubovskaya, E, Mejia, E, Byrnes, J, Hambardjieva, E, Garcia-Diaz, M. | 登録日 | 2010-05-03 | 公開日 | 2010-06-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.786 Å) | 主引用文献 | Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell(Cambridge,Mass.), 141, 2010
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5N2O
| Structure Of P63 SAM Domain L514F Mutant Causative Of AEC Syndrome | 分子名称: | Tumor protein 63 | 著者 | Rinnenthal, J, Wuerz, J.M, Osterburg, C, Guentert, P, Doetsch, V. | 登録日 | 2017-02-08 | 公開日 | 2018-02-07 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6QJW
| TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium | 分子名称: | 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | 登録日 | 2019-01-27 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
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3MVA
| Crystal structure of human MTERF1 bound to the termination sequence | 分子名称: | 5'-D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)-3'), 5'-D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)-3'), Transcription termination factor, ... | 著者 | Yakubovskaya, E, Mejia, E, Byrnes, J, Hambardjieva, E, Garcia-Diaz, M. | 登録日 | 2010-05-03 | 公開日 | 2010-06-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell(Cambridge,Mass.), 141, 2010
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5FLV
| Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region | 分子名称: | 5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3', 5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3', HOMEOBOX PROTEIN NKX-2.5, ... | 著者 | Stirnimann, C.U, Glatt, S, Mueller, C.W. | 登録日 | 2015-10-28 | 公開日 | 2016-02-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | 主引用文献 | Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell(Cambridge,Mass.), 164, 2016
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4GVP
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1RNL
| THE NITRATE/NITRITE RESPONSE REGULATOR PROTEIN NARL FROM NARL | 分子名称: | GLYCEROL, NITRATE/NITRITE RESPONSE REGULATOR PROTEIN NARL, PLATINUM (II) ION | 著者 | Baikalov, I, Schroder, I, Kaczor-Grzeskowiak, M, Grzeskowiak, K, Gunsalus, R.P, Dickerson, R.E. | 登録日 | 1996-04-17 | 公開日 | 1996-11-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of the Escherichia coli response regulator NarL. Biochemistry, 35, 1996
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3W5K
| Crystal structure of Snail1 and importin beta complex | 分子名称: | Importin subunit beta-1, ZINC ION, Zinc finger protein SNAI1 | 著者 | Choi, S, Yamashita, E, Yasuhara, N, Song, J, Son, S.Y, Won, Y.H, Shin, Y.S, Sekimoto, T, Park, I.Y, Yoneda, Y, Lee, S.J. | 登録日 | 2013-01-30 | 公開日 | 2014-03-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta. Acta Crystallogr.,Sect.D, 70, 2014
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2OXO
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6RBL
| TETR(D) E147A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM | 分子名称: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | 登録日 | 2019-04-10 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
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1KU2
| Crystal Structure of Thermus aquaticus RNA Polymerase Sigma Subunit Fragment Containing Regions 1.2 to 3.1 | 分子名称: | SULFATE ION, sigma factor sigA | 著者 | Campbell, E.A, Muzzin, O, Chlenov, M, Sun, J.L, Olson, C.A, Weinman, O, Trester-Zedlitz, M.L, Darst, S.A. | 登録日 | 2002-01-21 | 公開日 | 2002-04-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol.Cell, 9, 2002
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3WGG
| Crystal structure of RSP in complex with alpha-NAD+ | 分子名称: | Redox-sensing transcriptional repressor rex, SULFATE ION, alpha-Diphosphopyridine nucleotide | 著者 | Zheng, Y, Ko, T.-P, Guo, R.-T. | 登録日 | 2013-08-05 | 公開日 | 2014-08-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Binding mode of the oxidized alpha-anomer of NAD(+) to RSP, a Rex-family repressor Biochem.Biophys.Res.Commun., 456, 2015
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9C62
| P400 subcomplex of the native human TIP60 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | 登録日 | 2024-06-07 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (5.28 Å) | 主引用文献 | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9C6N
| ARP module of the human TIP60 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | 登録日 | 2024-06-07 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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7XGA
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7P2X
| E.coli GyrB24 with inhibitor KOB20 (EBL2583) | 分子名称: | (2Z)-2-[[4,5-bis(bromanyl)-1H-pyrrol-2-yl]carbonylimino]-3-(phenylmethyl)-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, PHOSPHATE ION | 著者 | Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Benek, O, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P. | 登録日 | 2021-07-06 | 公開日 | 2022-07-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | E.coli GyrB24 with inhibitor KOB20 (EBL2583) TO BE PUBLISHED
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5EU7
| Crystal structure of HIV-1 integrase catalytic core in complex with Fab | 分子名称: | FAB Heavy Chain, FAB light chain, Integrase | 著者 | Galilee, M, Griner, S.L, Stroud, R.M, Alian, A. | 登録日 | 2015-11-18 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure, 24, 2016
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6SI2
| p53 cancer mutant Y220S | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ... | 著者 | Joerger, A.C, Bauer, M.R, Structural Genomics Consortium (SGC) | 登録日 | 2019-08-08 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020
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1IW7
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6SHZ
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6SI4
| p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323 | 分子名称: | 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, GLYCEROL, ... | 著者 | Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2019-08-08 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020
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6SI0
| p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323 | 分子名称: | 1,2-ETHANEDIOL, 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2019-08-08 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020
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