Crystal structure of HIV-1 integrase catalytic core in complex with Fab

Summary for 5EU7

DescriptorIntegrase, FAB Heavy Chain, FAB light chain, ... (4 entities in total)
Functional Keywordsintegrase, fab, hiv, viral protein
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585
Total number of polymer chains6
Total molecular weight129823
Galilee, M.,Griner, S.L.,Stroud, R.M.,Alian, A. (deposition date: 2015-11-18, release date: 2016-09-28, Last modification date: 2016-11-09)
Primary citation
Galilee, M.,Britan-Rosich, E.,Griner, S.L.,Uysal, S.,Baumgartel, V.,Lamb, D.C.,Kossiakoff, A.A.,Kotler, M.,Stroud, R.M.,Marx, A.,Alian, A.
The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Structure, 24:1936-1946, 2016
PubMed: 27692964 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2016.08.015
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23420 1.2% 1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-18