5EU7
Crystal structure of HIV-1 integrase catalytic core in complex with Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 153 | 16710.1 | 2 | UniProt (P04585) Pfam (PF00665) | Human immunodeficiency virus 1 (HIV-1) | Pr160Gag-Pol |
| 2 | C, D (E, F) | FAB Heavy Chain | polymer | 233 | 24927.6 | 2 | Homo sapiens (Human) | ||
| 3 | E, F (D, C) | FAB light chain | polymer | 214 | 23273.8 | 2 | Homo sapiens (Human) | ||
| 4 | G, H, I, J, K... (A, B, E, F, D...) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A, B: 57 - 209 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Ser 123 | Gly 1270 | conflict |
| Thr 124 | Ala 1271 | conflict |
| Lys 127 | Arg 1274 | conflict |
| Asp 131 | Trp 1278 | engineered mutation |
| Lys 185 | Phe 1332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 129823.0 | |
| All* | Total formula weight | 129823.0 |
