6SI0

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323

Summary for 6SI0

• Entry DOI: 10.2210/pdb6si0/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION, 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, ... (7 entities in total)
• Functional Keywords: p53, transcription factor, tumor suppressor, cancer therapy, dna-binding domain, oncogenic mutant, protein misfolding, druggable surface crevice, small-molecule stabilizer, mutant p53 rescue, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50227.78

Authors

Joerger, A.C.,Kraemer, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-08-08, release date: 2020-02-19, Last modification date: 2024-01-24)

• Primary citation: Bauer, M.R.,Kramer, A.,Settanni, G.,Jones, R.N.,Ni, X.,Khan Tareque, R.,Fersht, A.R.,Spencer, J.,Joerger, A.C.; Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.; Acs Chem.Biol., 15:657-668, 2020; PubMed: 31990523; DOI: 10.1021/acschembio.9b00748

Experimental method

X-RAY DIFFRACTION (1.53 Å)