PDB: 2705 件ウェブページステータス検索Chemie searchBIRD

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5AEL	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597 分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate) 著者 Yang, G, Oldfield, E, No, J.H. 登録日 2014-12-26 公開日 2015-10-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
4YI5	Crystal structure of Gpb in complex with 4b 分子名称: Glycogen phosphorylase, muscle form, INOSINIC ACID, ... 著者 Kantsadi, A.L, Chatzileontiadou, D.S.M, Stravodimos, G.A, Leonidas, D.D. 登録日 2015-02-27 公開日 2015-11-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N -( beta-D-glucopyranosyl) urea inhibitors. Curr Top Med Chem, 15, 2015
5E8K	Crystal structure of polyprenyl pyrophosphate synthase 2 from Arabidopsis thaliana 分子名称: Geranylgeranyl pyrophosphate synthase 10, mitochondrial 著者 Wang, C, Chen, Q, Fan, D, Li, J, Wang, G, Zhang, P. 登録日 2015-10-14 公開日 2015-11-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.028 Å) 主引用文献 Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant, 9, 2016
4X38	Gallus interleukin-1 beta mutant - E118A 分子名称: IL-1 beta 著者 Yin, H.S, Cheng, W.T. 登録日 2014-11-28 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Gallus interleukin-1 beta mutant - E118A To Be Published
4X39	Gallus interleukin-1 beta mutant - T117A 分子名称: IL-1 beta 著者 Yin, H.S, Cheng, W.T. 登録日 2014-11-28 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Gallus interleukin-1 beta mutant - T117A To Be Published
4XFU	Structure of IL-18 SER Mutant V 分子名称: Interleukin-18 著者 Krumm, B.E, Meng, X, Xiang, Y, Deng, J. 登録日 2014-12-29 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFT	Structure of IL-18 SER Mutant III 分子名称: DIMETHYL SULFOXIDE, Interleukin-18 著者 Krumm, B.E, Meng, X, Xiang, Y, Deng, J. 登録日 2014-12-29 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
5XN6	Heterodimer crystal structure of geranylgeranyl diphosphate synthases 1 with GGPPS Recruiting Protein(OsGRP) from Oryza sativa 分子名称: Os02g0668100 protein, Os07g0580900 protein 著者 Wang, C, Zhou, F, Lu, S, Zhang, P. 登録日 2017-05-18 公開日 2017-06-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.598 Å) 主引用文献 A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1MJV	DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A) 分子名称: Vascular Endothelial Growth Factor A 著者 Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H. 登録日 2002-08-28 公開日 2002-12-11 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor J.Biol.Chem., 277, 2002
1BJ1	VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY 分子名称: Fab fragment, heavy chain, light chain, ... 著者 Muller, Y.A, Christinger, H.W, De Vos, A.M. 登録日 1998-06-30 公開日 1999-01-13 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure, 6, 1998
3ZCP	Rabbit muscle glycogen phosphorylase b in complex with N- cyclohexancarbonyl-N-beta-D-glucopyranosyl urea determined at 1.83 A resolution 分子名称: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(cyclohexylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, ... 著者 Chrysina, E.D, Nagy, V, Felfoldi, N, Konya, B, Telepo, K, Praly, J.P, Docsa, T, Gergely, P, Alexacou, K.M, Hayes, J.M, Konstantakaki, M, Kardakaris, R, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G, Somsak, L. 登録日 2012-11-21 公開日 2013-12-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published
1CZ8	VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY 分子名称: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... 著者 Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. 登録日 1999-09-01 公開日 2000-03-20 最終更新日 2017-04-05 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293, 1999
1MD6	High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity 分子名称: interleukin 1 family, member 5 (delta) 著者 Pei, X.Y, Dunn, E.F, Gay, N.J, O'Neill, L.A. 登録日 2002-08-07 公開日 2003-09-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity. Biochemistry, 42, 2003
1E4O	Phosphorylase recognition and phosphorolysis of its oligosaccharide substrate: answers to a long outstanding question 分子名称: MALTODEXTRIN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose 著者 Watson, K.A, McCleverty, C, Geremia, S, Cottaz, S, Driguez, H, Johnson, L.N. 登録日 2000-07-11 公開日 2000-08-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Phosphorylase Recognition and Phosphorylysis of its Oligosaccharide Substrate: Answers to a Long Outstanding Question Embo J., 18, 1999
1DQR	CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE, A GLYCOLYTIC ENZYME THAT MOONLIGHTS AS NEUROLEUKIN, AUTOCRINE MOTILITY FACTOR, AND DIFFERENTIATION MEDIATOR 分子名称: 6-PHOSPHOGLUCONIC ACID, PHOSPHOGLUCOSE ISOMERASE 著者 Bahnson, B.J, Jeffery, C.J, Ringe, D, Petsko, G.A. 登録日 2000-01-05 公開日 2000-02-09 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry, 39, 2000
1L5S	Human liver glycogen phosphorylase complexed with uric acid, N-Acetyl-beta-D-glucopyranosylamine, and CP-403,700 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Glycogen phosphorylase, liver form, ... 著者 Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. 登録日 2002-03-07 公開日 2002-12-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem.Biol., 9, 2002
1C50	IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B 分子名称: 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE 著者 Oikonomakos, N.G, Skamnaki, V.T, Tsitsanou, K.E, Gavalas, N.G, Johnson, L.N. 登録日 1999-12-15 公開日 1999-12-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A new allosteric site in glycogen phosphorylase b as a target for drug interactions. Structure Fold.Des., 8, 2000
1LWN	Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution 分子名称: PYRIDOXAL-5'-PHOSPHATE, alpha-D-glucopyranose, glycogen phosphorylase 著者 Oikonomakos, N.G, Chrysina, E.D, Kosmopoulou, M, Leonidas, D.D. 登録日 2002-06-01 公開日 2002-06-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS, 1647, 2003
1C8K	FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE 分子名称: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE 著者 Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Tsitsanou, K.E, Johnson, L.N. 登録日 2000-05-11 公開日 2000-05-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. J.Biol.Chem., 275, 2000
1C7R	THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE/AUTOCRINE MOTILITY FACTOR/NEUROLEUKIN COMPLEXED WITH ITS CARBOHYDRATE PHOSPHATE INHIBITORS AND ITS SUBSTRATE RECOGNITION MECHANISM 分子名称: 5-PHOSPHOARABINONIC ACID, PHOSPHOGLUCOSE ISOMERASE 著者 Chou, C.-C, Meng, M, Sun, Y.-J, Hsiao, C.-D. 登録日 2000-03-02 公開日 2000-09-13 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition. J.Biol.Chem., 275, 2000
1C7Q	THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE/AUTOCRINE MOTILITY FACTOR/NEUROLEUKIN COMPLEXED WITH ITS CARBOHYDRATE PHOSPHATE INHIBITORS AND ITS SUBSTRATE RECOGNITION MECHANISM 分子名称: N-BROMOACETYL-AMINOETHYL PHOSPHATE, PHOSPHOGLUCOSE ISOMERASE 著者 Chou, C.-C, Meng, M, Sun, Y.-J, Hsiao, C.-D. 登録日 2000-03-02 公開日 2000-09-13 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition. J.Biol.Chem., 275, 2000
4BQE	Arabidopsis thaliana Cytosolic Alpha-1,4-glucan Phosphorylase (PHS2) 分子名称: ALPHA-GLUCAN PHOSPHORYLASE 2,4-GLUCAN PHOSPHORYLASE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 O'Neill, E.C, Rashid, A.M, Stevenson, C.E.M, Hetru, A.C, Gunning, A.P, Rejzek, M, Nepogodiev, S.A, Bornemann, S, Lawson, D.M, Field, R.A. 登録日 2013-05-30 公開日 2014-02-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Sugar-Coated Sensor Chip and Nanoparticle Surfaces for the in Vitro Enzymatic Synthesis of Starch-Like Materials Chem.Sci., 5, 2014
3ZCV	Rabbit muscle glycogen phosphorylase b in complex with N-(indol-2- carbonyl)-N-beta-D-glucopyranosyl urea determined at 1.8 A resolution 分子名称: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(1H-indol-2-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, ... 著者 Chrysina, E.D, Nagy, V, Felfoldi, N, Konya, B, Telepo, K, Praly, J.P, Docsa, T, Gergely, P, Alexacou, K.M, Hayes, J.M, Konstantakaki, M, Kardakaris, R, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G, Somsak, L. 登録日 2012-11-21 公開日 2013-12-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published
3ZMB	Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound fragment SPB02696. 分子名称: 3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Schmidberger, J.W, Schnell, R, Schneider, G. 登録日 2013-02-07 公開日 2014-02-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Acta Crystallogr.,Sect.D, 71, 2015
3ZOU	Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound fragment SPB02696, and substrate geranyl pyrophosphate. 分子名称: 3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid, DIMETHYL SULFOXIDE, FARNESYL PYROPHOSPHATE SYNTHASE, ... 著者 Schmidberger, J.W, Schnell, R, Schneider, G. 登録日 2013-02-25 公開日 2014-03-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa Acta Crystallogr.,Sect.D, 71, 2015

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