5AEL
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597
Summary for 5AEL
Entry DOI | 10.2210/pdb5ael/pdb |
Descriptor | FARNESYL PYROPHOSPHATE SYNTHASE, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate), MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | TRYPANOSOMA BRUCEI |
Total number of polymer chains | 2 |
Total formula weight | 84864.36 |
Authors | Yang, G.,Oldfield, E.,No, J.H. (deposition date: 2014-12-26, release date: 2015-10-28, Last modification date: 2024-01-10) |
Primary citation | Yang, G.,Zhu, W.,Kim, K.,Byun, S.Y.,Choi, G.,Wang, K.,Cha, J.S.,Cho, H.,Oldfield, E.,No, J.H. Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59:7530-, 2015 Cited by PubMed: 26392508DOI: 10.1128/AAC.01873-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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