5AEL

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597

Summary for 5AEL

• Entry DOI: 10.2210/pdb5ael/pdb
• Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: TRYPANOSOMA BRUCEI
• Total number of polymer chains: 2
• Total formula weight: 84864.36

Authors

Yang, G.,Oldfield, E.,No, J.H. (deposition date: 2014-12-26, release date: 2015-10-28, Last modification date: 2024-01-10)

• Primary citation: Yang, G.,Zhu, W.,Kim, K.,Byun, S.Y.,Choi, G.,Wang, K.,Cha, J.S.,Cho, H.,Oldfield, E.,No, J.H.; Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.; Antimicrob.Agents Chemother., 59:7530-, 2015; PubMed: 26392508; DOI: 10.1128/AAC.01873-15

Experimental method

X-RAY DIFFRACTION (2.6 Å)