3ZCV

Rabbit muscle glycogen phosphorylase b in complex with N-(indol-2- carbonyl)-N-beta-D-glucopyranosyl urea determined at 1.8 A resolution

Summary for 3ZCV

• Entry DOI: 10.2210/pdb3zcv/pdb
• Related: 3ZCP 3ZCQ 3ZCR 3ZCS 3ZCT 3ZCU
• Descriptor: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(1H-indol-2-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: transferase, n-acyl-n-beta-d-glucopyranosyl ureas, inhibitor, hypoglycaemic agents, structure- based ligand design
• Biological source: ORYCTOLAGUS CUNICULUS (RABBIT)
• Total number of polymer chains: 1
• Total formula weight: 98496.28

Authors

Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L. (deposition date: 2012-11-21, release date: 2013-12-11, Last modification date: 2023-12-20)

• Primary citation: Chrysina, E.D.,Nagy, V.,Felfoldi, N.,Konya, B.,Telepo, K.,Praly, J.P.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Hayes, J.M.,Konstantakaki, M.,Kardakaris, R.,Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G.,Somsak, L.; Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents; To be Published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)