1C8K

FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE

Summary for 1C8K

Entry DOI	10.2210/pdb1c8k/pdb
Descriptor	PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, ... (4 entities in total)
Functional Keywords	glycogen metabolism, glycogen phosphorylase b, inhibition, inhibitor binding site, antitumour agent, transferase
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	97940.18
Authors	Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T.,Tsitsanou, K.E.,Johnson, L.N. (deposition date: 2000-05-11, release date: 2000-05-24, Last modification date: 2023-12-27)
Primary citation	Oikonomakos, N.G.,Schnier, J.B.,Zographos, S.E.,Skamnaki, V.T.,Tsitsanou, K.E.,Johnson, L.N. Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. J.Biol.Chem., 275:34566-34573, 2000 Cited by PubMed: 10924512 DOI: 10.1074/jbc.M004485200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation