8HPO
| Cryo-EM structure of a SIN3/HDAC complex from budding yeast | 分子名称: | Histone deacetylase RPD3, PHOSPHOTHREONINE, POTASSIUM ION, ... | 著者 | Guo, Z, Zhan, X, Wang, C. | 登録日 | 2022-12-12 | 公開日 | 2023-05-03 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure of a SIN3-HDAC complex from budding yeast. Nat.Struct.Mol.Biol., 30, 2023
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7OCB
| Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-2N-[2-(dimethylamino)ethyl]-6-methoxy-4N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine, CHLORIDE ION, ... | 著者 | Johansson, C, Krojer, T, Park, K, Xiong, Y, Jin, J, Oppermann, U. | 登録日 | 2021-04-26 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B To Be Published
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8I03
| Cryo-EM structure of the SIN3L complex from S. pombe | 分子名称: | Chromatin modification-related protein png2, Histone deacetylase clr6, POTASSIUM ION, ... | 著者 | Wang, C, Guo, Z, Zhan, X. | 登録日 | 2023-01-10 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
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7K7T
| Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP | 分子名称: | Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Klein, B.J, Tencer, A.H, Kutateladze, T.G. | 登録日 | 2020-09-24 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Molecular mechanism of the MORC4 ATPase activation. Nat Commun, 11, 2020
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8ESC
| Structure of the Yeast NuA4 Histone Acetyltransferase Complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... | 著者 | Patel, A.B, Zukin, S.A, Nogales, E. | 登録日 | 2022-10-13 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Elife, 11, 2022
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6E2H
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4UXN
| LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, ... | 著者 | Rodriguez, V, Valente, S, Stazi, G, Lucidi, A, Mercurio, C, Vianello, P, Ciossani, G, Mattevi, A, Botrugno, O.A, Dessanti, P, Minucci, S, Varasi, M, Mai, A. | 登録日 | 2014-08-27 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells Chemmedchem, 6, 2015
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7ZEY
| Complex Cyp33-RRM : MLL1-PHD3 | 分子名称: | MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION | 著者 | Blatter, M, Allain, F, Meylan, C. | 登録日 | 2022-03-31 | 公開日 | 2022-04-13 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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4UF0
| Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid. | 分子名称: | 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, FE (II) ION, ... | 著者 | Srikannathasan, V, Johansson, C, Gileadi, C, Tobias, K, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. | 登録日 | 2014-12-22 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
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6VHF
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6TUY
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3UR4
| Crystal structure of human WD repeat domain 5 with compound | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | 著者 | Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-21 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
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9FWG
| LSD1/CoREST bound to bomedemstat | 分子名称: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | 著者 | Speranzini, V, Mattevi, A. | 登録日 | 2024-06-30 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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9GII
| Jumonji domain-containing protein 2A with crystallization epitope mutation R913A | 分子名称: | GLYCEROL, Lysine-specific demethylase 4A, SULFATE ION | 著者 | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | 登録日 | 2024-08-19 | 公開日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To be published
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6R1U
| Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 2 | 分子名称: | DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, Histone H2A, ... | 著者 | Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. | 登録日 | 2019-03-15 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
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6R25
| Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 | 分子名称: | DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, H2B, ... | 著者 | Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. | 登録日 | 2019-03-15 | 公開日 | 2019-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.61 Å) | 主引用文献 | A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
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2RSD
| Solution structure of the plant homeodomain (PHD) of the E3 SUMO ligase Siz1 from rice | 分子名称: | E3 SUMO-protein ligase SIZ1, ZINC ION | 著者 | Shindo, H, Tsuchiya, W, Suzuki, R, Yamazaki, T. | 登録日 | 2012-01-12 | 公開日 | 2012-08-15 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2 Febs Lett., 586, 2012
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6I8L
| Crystal structure of Spindlin1 in complex with the inhibitor TD001851a | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine, ... | 著者 | Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2018-11-20 | 公開日 | 2018-12-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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6I8Y
| Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, ... | 著者 | Srikannathasan, V, Johansson, C, Gileadi, C, Shrestha, L, Sorrell, F.J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2018-11-21 | 公開日 | 2018-12-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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6I8B
| Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn | 分子名称: | 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, GLYCINE, ... | 著者 | Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2018-11-19 | 公開日 | 2018-12-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
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6QPL
| Crystal structure of Spindlin1 in complex with the inhibitor MS31 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Johansson, C, Krojer, T, Xiong, Y, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. | 登録日 | 2019-02-14 | 公開日 | 2019-07-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J.Med.Chem., 62, 2019
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8BOX
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8BOP
| LSD1-CoREST in complex with AW4, long soaking | 分子名称: | Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[7,8-dimethyl-2,4-bis(oxidanylidene)-5-[3-[4-(3-phenylphenyl)phenyl]propanoyl]-1~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | 著者 | Caroli, J, Mattevi, A. | 登録日 | 2022-11-15 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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6TE1
| Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol | 分子名称: | 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Pasqualato, S, Cecatiello, V. | 登録日 | 2019-11-11 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. Acs Med.Chem.Lett., 11, 2020
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6WKR
| PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | 分子名称: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | 登録日 | 2020-04-16 | 公開日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
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