3UR4

Crystal structure of human WD repeat domain 5 with compound

Summary for 3UR4

• Entry DOI: 10.2210/pdb3ur4/pdb
• Descriptor: WD repeat-containing protein 5, methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methylpiperazin-1-yl)benzoate, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, transcription, wd repeat domain 5, wdr5, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P61964
• Total number of polymer chains: 2
• Total formula weight: 70344.11

Authors

Dong, A.,Dombrovski, L.,Senisterra, G.,Wernimont, A.,Wasney, G.A.,Allali Hassani, A.,Nguyen, K.T.,Smil, D.,Bolshan, Y.,Hajian, T.,Poda, G.,Chau, I.,Al-Awar, R.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.,Schapira, M.,Vedadi, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-11-21, release date: 2011-12-14, Last modification date: 2023-09-13)

• Primary citation: Senisterra, G.,Wu, H.,Allali-Hassani, A.,Wasney, G.A.,Barsyte-Lovejoy, D.,Dombrovski, L.,Dong, A.,Nguyen, K.T.,Smil, D.,Bolshan, Y.,Hajian, T.,He, H.,Seitova, A.,Chau, I.,Li, F.,Poda, G.,Couture, J.F.,Brown, P.J.,Al-Awar, R.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M.; Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.; Biochem. J., 449:151-159, 2013; PubMed: 22989411; DOI: 10.1042/BJ20121280

Experimental method

X-RAY DIFFRACTION (1.8 Å)