3UR4

Crystal structure of human WD repeat domain 5 with compound

Summary for 3UR4

DescriptorWD repeat-containing protein 5, methyl 3-[(3-methoxybenzoyl)amino]-4-(4-methylpiperazin-1-yl)benzoate, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywordsstructural genomics, structural genomics consortium, sgc, transcription, wd repeat domain 5, wdr5, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P61964
Total number of polymer chains2
Total molecular weight70344.11
Authors
Primary citation
Senisterra, G.,Wu, H.,Allali-Hassani, A.,Wasney, G.A.,Barsyte-Lovejoy, D.,Dombrovski, L.,Dong, A.,Nguyen, K.T.,Smil, D.,Bolshan, Y.,Hajian, T.,He, H.,Seitova, A.,Chau, I.,Li, F.,Poda, G.,Couture, J.F.,Brown, P.J.,Al-Awar, R.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449:151-159, 2013
PubMed: 22989411 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20121280
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.215300.4%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload