PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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1HBW	Solution nmr structure of the dimerization domain of the yeast transcriptional activator Gal4 (residues 50-106) 分子名称: REGULATORY PROTEIN GAL4 著者 Hidalgo, P, Ansari, A.Z, Schmidt, P, Hare, B, Simkovic, N, Farrell, S, Shin, E.J, Ptashne, M, Wagner, G. 登録日 2001-04-20 公開日 2001-05-10 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Recruitment of the Transcriptional Machinery Through Gal11P: Structure and Interactions of the GAL4 Dimerization Domain Genes Dev., 15, 2001
1TKX	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 分子名称: 4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE, Pol polyprotein, Reverse transcriptase, ... 著者 Ren, J, Hopkins, A.L, Stuart, D.I, Stammers, D.K. 登録日 2004-06-09 公開日 2004-12-07 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2. J.Med.Chem., 47, 2004
2OPR	Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, Reverse transcriptase/ribonuclease H, p51 RT 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
2OPS	Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
8BAO	Dysgonamonadaceae bacterium CRISPR ancillary nuclease 2 分子名称: BROMIDE ION, Cyclic tetra-adenylate (cA4), DUF1887 family protein, ... 著者 Li, A.W.H, Doherty, A.J. 登録日 2022-10-11 公開日 2022-11-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Reverse transcriptases prime DNA synthesis. Nucleic Acids Res., 51, 2023
2OPQ	Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
2OPP	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X. 分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Chan, S.J.H, Kleim, J, Stammers, D.K. 登録日 2007-01-30 公開日 2007-05-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
1VK6	Crystal structure of NADH pyrophosphatase (1790429) from Escherichia coli k12 at 2.20 A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, NADH pyrophosphatase, ZINC ION 著者 Joint Center for Structural Genomics (JCSG) 登録日 2004-04-30 公開日 2004-05-11 最終更新日 2023-01-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of NADH pyrophosphatase (1790429) from Escherichia coli k12 at 2.20 A resolution To be published
2R2U	Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment 分子名称: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide, ... 著者 Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M. 登録日 2007-08-27 公開日 2008-07-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc.Natl.Acad.Sci.Usa, 105, 2008
2R2R	d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment 分子名称: DNA (5'-D(*DAP*DTP*DTP*DAP*DGP*DTP*DTP*DA)-3'), DNA (5'-D(P*DTP*DAP*DAP*DCP*DTP*DAP*DAP*DT)-3'), Reverse transcriptase 著者 Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M. 登録日 2007-08-27 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc.Natl.Acad.Sci.Usa, 105, 2008
7ZR0	CryoEM structure of HSP90-CDC37-BRAF(V600E) complex. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... 著者 Oberoi, J, Pearl, L.H. 登録日 2022-05-03 公開日 2022-12-14 最終更新日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
7ZR5	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... 著者 Oberoi, J, Pearl, L.H. 登録日 2022-05-03 公開日 2022-12-14 最終更新日 2022-12-21 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
7ZR6	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... 著者 Oberoi, J, Pearl, L.H. 登録日 2022-05-03 公開日 2022-12-28 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
1FMB	EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793 分子名称: EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL 著者 Wlodawer, A, Gustchina, A, Zdanov, A, Kervinen, J. 登録日 1996-02-27 公開日 1996-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of equine infectious anemia virus proteinase complexed with an inhibitor. Protein Sci., 5, 1996
7S76	HBV CAPSID Y132A WITH COMPOUND 10b AT 2.5A RESOLUTION 分子名称: (1-methyl-1H-1,2,4-triazol-3-yl)methyl {(4S)-1-[(3-chloro-4-fluorophenyl)carbamoyl]-2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol-4-yl}carbamate, Capsid protein 著者 Olland, A.M, Suto, R.K. 登録日 2021-09-15 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The identification of highly efficacious functionalised tetrahydrocyclopenta[ c ]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly. Rsc Med Chem, 13, 2022
6LUR	Human PUF60 UHM domain (thioredoxin fusion) in complex with a small molecule binder 分子名称: 4-[2-[4-(aminomethyl)phenyl]phenyl]piperazin-2-one, Thioredoxin 1,Poly(U)-binding-splicing factor PUF60 著者 Takahashi, M, Hanzawa, H. 登録日 2020-01-30 公開日 2020-04-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Revisiting biomolecular NMR spectroscopy for promoting small-molecule drug discovery. J.Biomol.Nmr, 74, 2020
8T7T	CryoEM structure of the HisRS-like domain of human GCN2 分子名称: eIF-2-alpha kinase GCN2 著者 Yin, J.Z, Keszei, A.F.A, Mazhab-Jafari, M.T, Sicheri, F. 登録日 2023-06-21 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 CryoEM structure of the HisRS-like domain of human GCN2 To Be Published
8FFW	Cryo-EM structure of the GR-Hsp90-FKBP51 complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... 著者 Noddings, C.M, Agard, D.A. 登録日 2022-12-10 公開日 2023-11-01 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat.Struct.Mol.Biol., 30, 2023
5OKC	Crystal structure of the Ctf18-1-8 module from Ctf18-RFC 分子名称: 1,2-ETHANEDIOL, Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, ... 著者 Grabarczyk, D.B, Kisker, C. 登録日 2017-07-25 公開日 2017-12-20 最終更新日 2018-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis for the Recruitment of Ctf18-RFC to the Replisome. Structure, 26, 2018
2C3S	Structure Of Sars Cov Main Proteinase At 1.9 A (Ph6.5) 分子名称: SARS COV 3C-LIKE PROTEINASE 著者 Xu, T, Ooi, A, Lee, H.-C, Lescar, J. 登録日 2005-10-12 公開日 2005-10-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Sars Coronavirus Main Proteinase as an Active C2 Crystallographic Dimer. Acta Crystallogr.,Sect.F, 61, 2005
6EY7	Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound 分子名称: 4-[(4-fluorophenyl)methyl-methyl-amino]-2,4-bis(oxidanylidene)butanoic acid, CHLORIDE ION, MANGANESE (II) ION, ... 著者 Bongarzone, S, Nadal, M, Kaczmarska, Z, Machon, C, Alvarez, M, Albericio, F, Coll, M. 登録日 2017-11-10 公開日 2018-10-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Driven Discovery of alpha , gamma-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase. Acs Omega, 3, 2018
5W9C	Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen 分子名称: 4-HYDROXYTAMOXIFEN, Estrogen receptor 著者 Fanning, S.W, Greene, G.W. 登録日 2017-06-23 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
5W9D	Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen 分子名称: Endoxifen, Estrogen receptor 著者 Fanning, S.W, Greene, G.L. 登録日 2017-06-23 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6464 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
6CBZ	Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide 分子名称: ESTRADIOL, Estrogen receptor, GLYCEROL, ... 著者 Fanning, S.W, Greene, G.L. 登録日 2018-02-05 公開日 2018-02-28 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94, 2018
7OXO	human LonP1, R-state, incubated in AMPPCP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. 登録日 2021-06-22 公開日 2021-12-22 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022

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