5W9C

Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen

Summary for 5W9C

Entry DOI	10.2210/pdb5w9c/pdb
Descriptor	Estrogen receptor, 4-HYDROXYTAMOXIFEN (3 entities in total)
Functional Keywords	breast cancer, selective estrogen receptor modulator, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	115043.02
Authors	Fanning, S.W.,Greene, G.W. (deposition date: 2017-06-23, release date: 2018-06-13, Last modification date: 2023-10-04)
Primary citation	Maximov, P.Y.,Abderrahman, B.,Fanning, S.W.,Sengupta, S.,Fan, P.,Curpan, R.F.,Rincon, D.M.Q.,Greenland, J.A.,Rajan, S.S.,Greene, G.L.,Jordan, V.C. Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94:812-822, 2018 Cited by PubMed: 29739819 DOI: 10.1124/mol.117.111385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.802 Å)

Structure validation