5W9C
Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 249 | 28373.2 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, F, G, H (A, B, C, D) | 4-HYDROXYTAMOXIFEN | non-polymer | 387.5 | 4 | Chemie (OHT) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 307 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 306 | - | initiating methionine |
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113493.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1550.1 | |
| All* | Total formula weight | 115043.0 |
