5W9C
Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue OHT A 601 |
| Chain | Residue |
| A | LEU346 |
| A | VAL533 |
| A | PRO535 |
| A | HOH748 |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | ARG394 |
| A | LEU428 |
| A | LEU525 |
| A | ASN532 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue OHT B 601 |
| Chain | Residue |
| B | MET343 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | TRP383 |
| B | LEU387 |
| B | ARG394 |
| B | LEU428 |
| B | LEU525 |
| B | ASN532 |
| B | VAL533 |
| B | HOH727 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue OHT C 601 |
| Chain | Residue |
| C | LEU346 |
| C | THR347 |
| C | ALA350 |
| C | ASP351 |
| C | GLU353 |
| C | ARG394 |
| C | MET421 |
| C | LEU525 |
| C | ASN532 |
| C | VAL533 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue OHT D 601 |
| Chain | Residue |
| D | MET343 |
| D | LEU346 |
| D | THR347 |
| D | ALA350 |
| D | ASP351 |
| D | GLU353 |
| D | ARG394 |
| D | LEU428 |
| D | VAL533 |
| D | HOH750 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| D | GLU353 | |
| D | ARG394 | |
| D | HIS524 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 | |
| C | GLU353 | |
| C | ARG394 | |
| C | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR537 | |
| C | TYR537 | |
| D | TYR537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
| C | CYS447 | |
| D | CYS447 |
