2OPQ
Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Summary for 2OPQ
| Entry DOI | 10.2210/pdb2opq/pdb |
| Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ... (5 entities in total) |
| Functional Keywords | hiv-1 reverse transcriptase, aids, nnrti, gw420867x, drug resistance, transferase |
| Biological source | HIV-1 M:B_HXB2R More |
| Cellular location | Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
| Total number of polymer chains | 2 |
| Total formula weight | 111985.17 |
| Authors | Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.,Stammers, D.K. (deposition date: 2007-01-30, release date: 2007-05-22, Last modification date: 2023-12-27) |
| Primary citation | Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.P.,Stammers, D.K. Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50:2301-2309, 2007 Cited by PubMed: 17441703DOI: 10.1021/jm061117m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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