2OPQ
Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 534 | 61920.8 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | HIV-1 M:B_HXB2R | |
| 2 | B (B) | p51 RT | polymer | 424 | 49689.1 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | HIV-1 M:B_HXB2R | |
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE | non-polymer | 280.3 | 1 | Chemie (HBQ) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 4 - 537 (UniProt: P04585)
B: 5 - 428 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Ile 100 | Leu 687 | engineered mutation |
| Csd 280 | Cys 867 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Ile 100 | Leu 687 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111609.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 375.3 | |
| All* | Total formula weight | 111985.2 |
