2OPQ

Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H	polymer	534	61920.8	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	HIV-1 M:B_HXB2R
2	B	p51 RT	polymer	424	49689.1	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	HIV-1 M:B_HXB2R
3	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	A	ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE	non-polymer		280.3	1	Chemie (HBQ)
5		water	water		18.0	25	Chemie (HOH)

Sequence modifications

A: 4 - 537 (UniProt: P04585)

PDB	External Database	Details
Ile 100	Leu 687	engineered mutation
Csd 280	Cys 867	modified residue

B: 5 - 428 (UniProt: P04585)

PDB	External Database	Details
Ile 100	Leu 687	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111609.9
Non-Polymers*	Number of molecules	2
	Total formula weight	375.3
All*	Total formula weight	111985.2

*Water molecules are not included.