1TKX

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745

Summary for 1TKX

DescriptorPol polyprotein, Reverse transcriptase, Chain A, Pol polyprotein, Reverse transcriptase, Chain B, 4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, nnrti, gw490745, drug design, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585 P04585
Total number of polymer chains2
Total molecular weight116279.31
Authors
Ren, J.,Hopkins, A.L.,Stuart, D.I.,Stammers, D.K. (deposition date: 2004-06-09, release date: 2004-12-07, Last modification date: 2018-01-31)
Primary citation
Freeman, G.A.,Andrews Iii, C.W.,Hopkins, A.L.,Lowell, G.S.,Schaller, L.T.,Cowan, J.R.,Gonzales, S.S.,Koszalka, G.W.,Hazen, R.J.,Boone, L.R.,Ferris, R.G.,Creech, K.L.,Roberts, G.B.,Short, S.A.,Weaver, K.,Reynolds, D.J.,Milton, J.,Ren, J.,Stuart, D.I.,Stammers, D.K.,Chan, J.H.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
J.Med.Chem., 47:5923-5936, 2004
PubMed: 15537347 (PDB entries with the same primary citation)
DOI: 10.1021/jm040072r
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.85 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238243.1%7.3%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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