2R2U

Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment

Summary for 2R2U

• Entry DOI: 10.2210/pdb2r2u/pdb
• Related: 2R2R 2R2S 2R2T
• Descriptor: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), Reverse transcriptase, ... (5 entities in total)
• Functional Keywords: bleomycin, drug-dna complex, protein-dna complex, mmlv rt, aspartyl protease, dna integration, dna recombination, endonuclease, hydrolase, multifunctional enzyme, nuclease, nucleotidyltransferase, protease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna
• Biological source: Moloney murine leukemia virus (MoMLV)
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p15: Virion . Capsid protein p30: Virion . Nucleocapsid protein p10: Virion : P03355
• Total number of polymer chains: 3
• Total formula weight: 33795.78

Authors

Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M. (deposition date: 2007-08-27, release date: 2008-07-22, Last modification date: 2023-08-30)

• Primary citation: Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M.; Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.; Proc.Natl.Acad.Sci.Usa, 105:5052-5056, 2008; PubMed: 18362349; DOI: 10.1073/pnas.0708143105

Experimental method

X-RAY DIFFRACTION (2.3 Å)