4MS6
| Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue | 分子名称: | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, ACETIC ACID, Leukotriene A-4 hydrolase, ... | 著者 | Stsiapanava, A, Rinaldo-Matthis, A, Haeggstrom, J.Z. | 登録日 | 2013-09-18 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4NAQ
| Crystal structure of porcine aminopeptidase-N complexed with poly-alanine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Chen, L, Lin, Y.L, Peng, G, Li, F. | 登録日 | 2013-10-22 | 公開日 | 2013-12-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4NZ8
| Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Chen, L, Lin, Y.L, Peng, G, Li, F. | 登録日 | 2013-12-11 | 公開日 | 2013-12-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4OU3
| Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | 著者 | Liu, C, Yang, Y, Chen, L, Lin, Y.-L, Li, F. | 登録日 | 2014-02-14 | 公開日 | 2014-11-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy. J.Biol.Chem., 289, 2014
|
|
4PU2
| Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine L-(R)-LeuP | 分子名称: | Aminopeptidase N, GLYCEROL, LEUCINE PHOSPHONIC ACID, ... | 著者 | Nocek, B, Vassiliou, S, Berlicki, L, Mulligan, R, Mucha, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-03-11 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | 主引用文献 | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine To be Published
|
|
4PVB
| Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP) | 分子名称: | Aminopeptidase N, PHOSPHATE ION, SULFATE ION, ... | 著者 | Nocek, B, Vassiliou, S, Berlicki, L, Mulligan, R, Mucha, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-03-16 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP) To be Published
|
|
4PW4
| Crystal structure of Aminopeptidase N in complex with phosphonic acid analogue of homophenylalanine L-(R)-hPheP | 分子名称: | Aminopeptidase N, GLYCEROL, IMIDAZOLE, ... | 著者 | Nocek, B, Mulligan, R, Vassiliou, S, Berlicki, L, Mucha, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-03-18 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of Aminopeptidase N in complex with phosphonic analogs of homophenylalanine TO BE PUBLISHED
|
|
4P8Q
| Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ... | 著者 | Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W. | 登録日 | 2014-03-31 | 公開日 | 2014-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Sci., 24, 2015
|
|
4Q4I
| Crystal structure of E.coli aminopeptidase N in complex with amastatin | 分子名称: | Amastatin, Aminopeptidase N, GLYCEROL, ... | 著者 | Reddi, R, Ganji, R.J, Addlagatta, A. | 登録日 | 2014-04-14 | 公開日 | 2015-04-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci., 24, 2015
|
|
4Q4E
| Crystal structure of E.coli aminopeptidase N in complex with actinonin | 分子名称: | ACTINONIN, Aminopeptidase N, GLYCEROL, ... | 著者 | Reddi, R, Ganji, R.J, Addlagatta, A. | 登録日 | 2014-04-14 | 公開日 | 2015-04-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci., 24, 2015
|
|
4PJ6
| Crystal Structure of Human Insulin Regulated Aminopeptidase with Lysine in Active Site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LYSINE, ... | 著者 | Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W. | 登録日 | 2014-05-12 | 公開日 | 2014-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Sci., 24, 2015
|
|
4QHP
| Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2) | 分子名称: | (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, Aminopeptidase N, ... | 著者 | Nocek, B, Joachimiak, A. | 登録日 | 2014-05-28 | 公開日 | 2014-09-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
|
|
4QIR
| Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe | 分子名称: | 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | 著者 | Nocek, B, Joachimiak, A, Berlicki, L, Vassiliou, S, Mucha, A. | 登録日 | 2014-06-01 | 公開日 | 2014-09-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
|
|
4QME
| Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe | 分子名称: | (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | 著者 | Nocek, B, Vassilious, S, Mulligan, R, Berlicki, L, Mucha, A, Joachimiak, A. | 登録日 | 2014-06-16 | 公開日 | 2014-10-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
|
|
4QPE
| Crystal structure of Aminopeptidase N in complex with N-cyclohexyl-1,2-diaminoethylphosphonic acid | 分子名称: | Aminopeptidase N, SULFATE ION, ZINC ION, ... | 著者 | Nocek, B, Mulligan, R, Berlicki, L, Vassilious, S, Mucha, A, Joachimiak, A. | 登録日 | 2014-06-23 | 公開日 | 2014-09-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
|
|
4QUO
| Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(3-CH2NH2) | 分子名称: | (2S)-2-[3-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, Aminopeptidase N, GLYCEROL, ... | 著者 | Nocek, B, Mulligan, R, Joachimiak, A, Vassiliou, S, Berlicki, L, Mucha, A. | 登録日 | 2014-07-11 | 公開日 | 2014-09-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
|
|
4R5X
| |
4R5T
| |
4R5V
| |
4R7L
| Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | 分子名称: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | 著者 | Ouyang, P, Cui, K, Lu, W, Huang, J. | 登録日 | 2014-08-27 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Human Leukotriene A4 Hydrolase in complex with SAHA To be Published
|
|
4RSY
| Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7 | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ACETIC ACID, IMIDAZOLE, ... | 著者 | Ouyang, P, Lu, W, Cui, K, Huang, J. | 登録日 | 2014-11-12 | 公開日 | 2015-12-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 To be Published
|
|
4WZ9
| APN1 from Anopheles gambiae | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, AGAP004809-PA, ALA-ALA-ALA-LYS-ALA, ... | 著者 | Atkinson, S.C, Armistead, J.S, Mathias, D.K, Sandeu, M.M, Tao, D, Borhani-Dizaji, N, Morlais, I, Dinglasan, R.R, Borg, N.A. | 登録日 | 2014-11-19 | 公開日 | 2015-06-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope. Nat.Struct.Mol.Biol., 22, 2015
|
|
4RVB
| Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase | 分子名称: | ACETATE ION, ACETIC ACID, GLYCEROL, ... | 著者 | Ouyang, P, Lu, W, Cui, K, Huang, J. | 登録日 | 2014-11-25 | 公開日 | 2015-12-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase To be Published
|
|
4X2U
| X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M1 Alanyl Aminopeptidase from P. falciparum | 分子名称: | (2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, GLYCEROL, M1 family aminopeptidase, ... | 著者 | Drinkwater, N, McGowan, S. | 登録日 | 2014-11-27 | 公開日 | 2015-02-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17. Proteins, 83, 2015
|
|
5AEN
| Structure of human Leukotriene A4 hydrolase in complex with inhibitor dimethyl(2- (4-phenoxyphenoxy)ethyl)amine | 分子名称: | IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine, ... | 著者 | Moser, D, Wittmann, S.K, Kramer, J, Blocher, R, Achenbach, J, Pogoryelov, D, Proschak, E. | 登録日 | 2015-01-06 | 公開日 | 2015-02-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.864 Å) | 主引用文献 | Peng: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation and Virtual Screening for Novel Ligands of Lta4H. J.Chem.Inf.Model., 55, 2015
|
|