4QHP

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2)

Summary for 4QHP

Entry DOI	10.2210/pdb4qhp/pdb
Descriptor	Aminopeptidase N, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, ... (8 entities in total)
Functional Keywords	zn-dependent, apn, (s)-2-[4-(aminomethyl)benzyl]-3-[(r)-1-amino-3-phenylpropyl(hydroxy)phosphoryl]propanoic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Neisseria meningitidis
Total number of polymer chains	1
Total formula weight	101206.96
Authors	Nocek, B.,Joachimiak, A. (deposition date: 2014-05-28, release date: 2014-09-24, Last modification date: 2023-12-06)
Primary citation	Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493 DOI: 10.1021/jm501071f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation