4QHP
Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2)
Summary for 4QHP
Entry DOI | 10.2210/pdb4qhp/pdb |
Descriptor | Aminopeptidase N, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, ... (8 entities in total) |
Functional Keywords | zn-dependent, apn, (s)-2-[4-(aminomethyl)benzyl]-3-[(r)-1-amino-3-phenylpropyl(hydroxy)phosphoryl]propanoic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Neisseria meningitidis |
Total number of polymer chains | 1 |
Total formula weight | 101206.96 |
Authors | Nocek, B.,Joachimiak, A. (deposition date: 2014-05-28, release date: 2014-09-24, Last modification date: 2023-12-06) |
Primary citation | Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493DOI: 10.1021/jm501071f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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