4QHP

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 32Q A 901

Chain	Residue
A	GLN115
A	HIS297
A	LYS315
A	GLU316
A	ASP323
A	TYR377
A	GLU378
A	ZN908
A	HOH1489
A	GLU117
A	MSE256
A	GLY257
A	ALA258
A	GLU260
A	VAL290
A	HIS293
A	GLU294

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 32R A 902

Chain	Residue
A	ASN156
A	PRO175
A	PHE176
A	ARG203
A	TYR241
A	ASP242
A	LEU243
A	ASP244
A	GOL907
A	HOH1063
A	HOH1234
A	HOH1613
A	HOH1635
A	HOH1766

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IMD A 903

Chain	Residue
A	HIS24
A	LYS35
A	ARG37

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 904

Chain	Residue
A	TYR196
A	PHE197
A	THR198
A	LYS227
A	HOH1760
A	HOH1834

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 905

Chain	Residue
A	PRO585
A	LYS586
A	HIS587
A	GLU588
A	LYS589
A	HOH1687
A	HOH1953

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 906

Chain	Residue
A	ALA692
A	THR696
A	ASN727
A	LEU730
A	ALA731
A	TYR747
A	VAL751
A	GLN762
A	HOH1061

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 907

Chain	Residue
A	ARG203
A	32R902

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 908

Chain	Residue
A	HIS293
A	HIS297
A	GLU316
A	32Q901

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 909

Chain	Residue
A	MSE469
A	THR470
A	ASP471
A	HOH1101
A	HOH1179
A	HOH1397
A	HOH1462
A	HOH1568

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 910

Chain	Residue
A	ASN655
A	ARG679
A	ARG683
A	LYS700
A	MSE704
A	HOH1558
A	HOH1804

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 911

Chain	Residue
A	ARG406

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 912

Chain	Residue
A	ARG636
A	ARG755
A	HOH1053
A	HOH1270
A	HOH1515
A	HOH1608
A	HOH1611
A	HOH1675
A	HOH1832

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 913

Chain	Residue
A	ARG277
A	HOH1688

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 914

Chain	Residue
A	THR565
A	ARG568
A	ARG569
A	HOH1298
A	HOH1664

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 915

Chain	Residue
A	ARG330
A	HOH1480
A	HOH1732

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 916

Chain	Residue
A	ARG499
A	HOH1466

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 917

Chain	Residue
A	GLN664
A	TYR666
A	ARG679
A	MSE704
A	HOH1471

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 918

Chain	Residue
A	ALA191
A	VAL192
A	ASN831
A	LYS838
A	LYS842
A	HOH1380
A	HOH1654

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHNW

Chain	Residue	Details
A	VAL290-TRP299

---