4R5V

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor

Summary for 4R5V

Entry DOI	10.2210/pdb4r5v/pdb
Related	3EBG 4R5T 4R5X 4R6T 4R76 4R7M
Descriptor	M1 family aminopeptidase, ZINC ION, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ... (5 entities in total)
Functional Keywords	protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum FcB1/Columbia
Cellular location	Cytoplasm: O96935
Total number of polymer chains	1
Total formula weight	105118.54
Authors	Drinkwater, N.,Mcgowan, S. (deposition date: 2014-08-22, release date: 2014-10-29, Last modification date: 2023-09-20)
Primary citation	Mistry, S.N.,Drinkwater, N.,Ruggeri, C.,Sivaraman, K.K.,Loganathan, S.,Fletcher, S.,Drag, M.,Paiardini, A.,Avery, V.M.,Scammells, P.J.,McGowan, S. Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57:9168-9183, 2014 Cited by PubMed: 25299353 DOI: 10.1021/jm501323a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation