4R5X
Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Summary for 4R5X
Entry DOI | 10.2210/pdb4r5x/pdb |
Related | 3EBG 4R5T 4R5V 4R6T 4R76 4R7M |
Descriptor | M1 family aminopeptidase, ZINC ION, GLYCEROL, ... (7 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum FcB1/Columbia |
Cellular location | Cytoplasm: O96935 |
Total number of polymer chains | 1 |
Total formula weight | 106402.39 |
Authors | Drinkwater, N.,Mcgowan, S. (deposition date: 2014-08-22, release date: 2014-10-29, Last modification date: 2024-02-28) |
Primary citation | Mistry, S.N.,Drinkwater, N.,Ruggeri, C.,Sivaraman, K.K.,Loganathan, S.,Fletcher, S.,Drag, M.,Paiardini, A.,Avery, V.M.,Scammells, P.J.,McGowan, S. Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57:9168-9183, 2014 Cited by PubMed: 25299353DOI: 10.1021/jm501323a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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