4QPE

Crystal structure of Aminopeptidase N in complex with N-cyclohexyl-1,2-diaminoethylphosphonic acid

Summary for 4QPE

Entry DOI	10.2210/pdb4qpe/pdb
Related	2GTQ 4PU2 4PVB 4QHP 4QIR 4QME
Descriptor	Aminopeptidase N, [(1R)-1-amino-2-(cyclohexylamino)ethyl]phosphonic acid, ZINC ION, ... (5 entities in total)
Functional Keywords	alanine aminopeptidase, aminopeptidase n, m1 family peptidases, n-cyclohexyl-1, 2-diaminoethylphosphonic acid, hydrolase
Biological source	Neisseria meningitidis MC58
Total number of polymer chains	1
Total formula weight	99922.71
Authors	Nocek, B.,Mulligan, R.,Berlicki, L.,Vassilious, S.,Mucha, A.,Joachimiak, A. (deposition date: 2014-06-23, release date: 2014-09-24, Last modification date: 2023-12-06)
Primary citation	Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493 DOI: 10.1021/jm501071f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.004 Å)

Structure validation