4QIR
Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe
Summary for 4QIR
Entry DOI | 10.2210/pdb4qir/pdb |
Related | 4PU2 4PVB 4PW4 4QHP 4QME 4QPE |
Descriptor | Aminopeptidase N, 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, GLYCEROL, ... (7 entities in total) |
Functional Keywords | alanine aminopeptidase, aminopeptidase n, m1 family peptidases, 3-{[(r)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(s)-2-benzylpropanoic acid, hydrolase |
Biological source | Neisseria meningitidis MC58 |
Total number of polymer chains | 1 |
Total formula weight | 100108.11 |
Authors | Nocek, B.,Joachimiak, A.,Berlicki, L.,Vassiliou, S.,Mucha, A. (deposition date: 2014-06-01, release date: 2014-09-24, Last modification date: 2023-12-06) |
Primary citation | Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493DOI: 10.1021/jm501071f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.701 Å) |
Structure validation
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