4QME
Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe
Summary for 4QME
Entry DOI | 10.2210/pdb4qme/pdb |
Related | 4QIR 4QPE |
Descriptor | Aminopeptidase N, (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, ZINC ION, ... (7 entities in total) |
Functional Keywords | apn, alanine aminopeptidase, m1 peptidase, 3-{[(r)-1-amino-3-phenylpropyl](hydroxy)phosphoryl}-(s)-2-benzylpropanoic acid, hydrolase |
Biological source | Neisseria meningitidis MC58 |
Total number of polymer chains | 1 |
Total formula weight | 99933.87 |
Authors | Nocek, B.,Vassilious, S.,Mulligan, R.,Berlicki, L.,Mucha, A.,Joachimiak, A. (deposition date: 2014-06-16, release date: 2014-10-01, Last modification date: 2023-12-06) |
Primary citation | Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493DOI: 10.1021/jm501071f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.601 Å) |
Structure validation
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