4QME

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe

Summary for 4QME

Entry DOI	10.2210/pdb4qme/pdb
Related	4QIR 4QPE
Descriptor	Aminopeptidase N, (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, ZINC ION, ... (7 entities in total)
Functional Keywords	apn, alanine aminopeptidase, m1 peptidase, 3-{[(r)-1-amino-3-phenylpropyl](hydroxy)phosphoryl}-(s)-2-benzylpropanoic acid, hydrolase
Biological source	Neisseria meningitidis MC58
Total number of polymer chains	1
Total formula weight	99933.87
Authors	Nocek, B.,Vassilious, S.,Mulligan, R.,Berlicki, L.,Mucha, A.,Joachimiak, A. (deposition date: 2014-06-16, release date: 2014-10-01, Last modification date: 2023-12-06)
Primary citation	Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493 DOI: 10.1021/jm501071f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.601 Å)

Structure validation