4QUO

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(3-CH2NH2)

Summary for 4QUO

Entry DOI	10.2210/pdb4quo/pdb
Related	2GTQ 4QHP 4QME
Descriptor	Aminopeptidase N, (2S)-2-[3-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, GLYCEROL, ... (7 entities in total)
Functional Keywords	m1 family aminopeptidase, metalloprotease, apn, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Neisseria meningitidis MC58
Total number of polymer chains	1
Total formula weight	100941.80
Authors	Nocek, B.,Mulligan, R.,Joachimiak, A.,Vassiliou, S.,Berlicki, L.,Mucha, A. (deposition date: 2014-07-11, release date: 2014-09-10, Last modification date: 2023-12-06)
Primary citation	Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493 DOI: 10.1021/jm501071f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation