4QUO

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(3-CH2NH2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016285	molecular_function	alanyl aminopeptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3DZ A 901

Chain	Residue
A	GLN115
A	HIS297
A	LYS315
A	GLU316
A	ASP323
A	TYR377
A	ZN907
A	HOH1210
A	HOH1562
A	GLU117
A	MSE256
A	GLY257
A	ALA258
A	GLU260
A	VAL290
A	HIS293
A	GLU294

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 902

Chain	Residue
A	ASP604
A	ASN605
A	ALA606
A	GLU671
A	TRP675
A	HOH1948

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 903

Chain	Residue
A	SER542
A	ASP543
A	ASP544
A	LYS589
A	HOH1763

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 904

Chain	Residue
A	THR282
A	TRP712
A	HOH1090
A	HOH1299
A	HOH1668
A	HOH1685
A	HOH1793
A	HOH1859
A	HOH1914

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 905

Chain	Residue
A	PHE163
A	SER164

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IMD A 906

Chain	Residue
A	ASP22
A	ARG37

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 907

Chain	Residue
A	HIS293
A	HIS297
A	GLU316
A	3DZ901

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3DZ A 908

Chain	Residue
A	ASN156
A	PRO175
A	PHE176
A	ARG203
A	ASN204
A	TYR241
A	ASP242
A	LEU243
A	ASP244
A	HOH1026
A	HOH1140
A	HOH1488
A	HOH1553
A	HOH1882
A	HOH1894
A	HOH1931
A	HOH2025

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 909

Chain	Residue
A	MSE469
A	THR470
A	ASP471
A	HOH1083
A	HOH1225
A	HOH1618
A	HOH1656
A	HOH1682

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 910

Chain	Residue
A	THR565
A	ARG568
A	ARG569
A	HOH1584
A	HOH1727
A	HOH1854
A	HOH1866

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 911

Chain	Residue
A	ARG449
A	LEU450
A	HOH1659
A	HOH1709

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 912

Chain	Residue
A	ALA191
A	VAL192
A	ASN831
A	LYS838
A	LYS842
A	HOH1196
A	HOH1441
A	HOH1490

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 913

Chain	Residue
A	ARG499
A	HOH1977

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 914

Chain	Residue
A	ARG636
A	ARG755
A	HOH1117
A	HOH1847
A	HOH1869
A	HOH1875

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 915

Chain	Residue
A	GLU162
A	HOH1198
A	LYS3
A	GLY161

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 916

Chain	Residue
A	ALA331
A	SER332
A	HOH1407
A	HOH1767

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 917

Chain	Residue
A	LEU402
A	ARG406

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 918

Chain	Residue
A	GLU521
A	ALA522
A	HOH1940

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHNW

Chain	Residue	Details
A	VAL290-TRP299

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