PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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6SID	Crystal structure of the C-lobe of drosophila Arc 1 at atomic resolution 分子名称: Activity-regulated cytoskeleton associated protein 1 著者 Hallin, E.I, Kursula, P. 登録日 2019-08-09 公開日 2019-08-28 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Plos One, 16, 2021
6ANL	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors 分子名称: Mitogen-activated protein kinase 14, TAK-715 著者 Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. 登録日 2017-08-14 公開日 2018-01-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
6SQ2	Structure of a phosphomimetic switch 2 variant of Rab8a in complex with the phospho-Rab binding domain of RILPL2 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RILP-like protein 2, ... 著者 Khan, A.R, Waschbusch, D. 登録日 2019-09-03 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.684 Å) 主引用文献 Structure of a phosphomimetic switch 2 variant of Rab8a in complex with the phospho-Rab binding domain of RILPL2 To Be Published
6S8S	Extended structure of the human DDX6 C-terminal domain in complex with an EDC3 FDF peptide 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Enhancer of mRNA-decapping protein 3, PHOSPHATE ION, ... 著者 Peter, D, Valkov, E. 登録日 2019-07-10 公開日 2019-09-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression. Genes Dev., 33, 2019
6SC6	dAb3/HOIP-RBR apo structure 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF31, SULFATE ION, ... 著者 Tsai, Y.-C.I, House, D, Rittinger, K. 登録日 2019-07-23 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases. Cell Chem Biol, 27, 2020
4XI7	Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with Jagged1 N-box peptide 分子名称: E3 ubiquitin-protein ligase MIB1, Jagged 1 N-box peptide, SULFATE ION, ... 著者 McMillan, B.J, Blacklow, S.C. 登録日 2015-01-06 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases. Mol.Cell, 57, 2015
1O84	Crystal Structure of Bacteriocin AS-48. N-decyl-beta-D-maltoside Bound. 分子名称: DECANE, GLYCEROL, PEPTIDE ANTIBIOTIC AS-48, ... 著者 Sanchez-Barrena, M.J, Martinez-Ripoll, M, Galvez, A, Valdivia, E, Maqueda, M, Cruz, V, Albert, A. 登録日 2002-11-25 公開日 2003-11-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of Bacteriocin as-48: From Soluble State to Membrane Bound State J.Mol.Biol., 334, 2003
4XIB	Crystal structure of the MZM-REP domains of Mind bomb 1 in complex with fly Delta N-box peptide 分子名称: Delta N-box peptide, E3 ubiquitin-protein ligase MIB1, SULFATE ION, ... 著者 McMillan, B.J, Blacklow, S.C. 登録日 2015-01-06 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.147 Å) 主引用文献 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases. Mol.Cell, 57, 2015
6B8O	WT Ig-like V Domain with Phosphatidylserine 分子名称: 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sudom, A, Wang, Z. 登録日 2017-10-09 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
6SC5	dAb3/HOIP-RBR-Ligand2 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF31, SULFATE ION, ... 著者 Tsai, Y.-C.I, Johansson, H, House, D, Rittinger, K. 登録日 2019-07-23 公開日 2019-11-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases. Cell Chem Biol, 27, 2020
6AQB	Structure of the SH3 domain of MLK3 bound to peptide generated from phage display 分子名称: 1,2-ETHANEDIOL, Chimera protein of MLK3-SH3 and MIP (E.C.2.7.11.25), PHOSPHATE ION 著者 Kall, S.K, Lavie, A. 登録日 2017-08-19 公開日 2018-07-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3. J. Biol. Chem., 293, 2018
6SQC	Crystal structure of complex between nuclear coactivator binding domain of CBP and [1040-1086]ACTR containing alpha-methylated Leu1055 and Leu1076 分子名称: 1,2-ETHANEDIOL, Maltose/maltodextrin-binding periplasmic protein,CREB-binding protein, Nuclear receptor coactivator 3, ... 著者 Bauer, V, Schmidtgall, B, Gogl, G, Dolenc, j, Osz, J, Kostmann, C, Mitschler, A, Cousido-Siah, A, Rochel, N, Trave, G, Kieffer, B, Torbeev, V. 登録日 2019-09-03 公開日 2020-09-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Conformational editing of intrinsically disordered protein by alpha-methylation. Chem Sci, 12, 2020
4XI6	Crystal structure of the MZM-REP domains of Mind bomb 1 分子名称: E3 ubiquitin-protein ligase MIB1, SULFATE ION, ZINC ION 著者 McMillan, B.J, Blacklow, S.C. 登録日 2015-01-06 公開日 2015-03-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases. Mol.Cell, 57, 2015
6SFK	Crystal structure of p38 alpha in complex with compound 81 (MCP42) 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 14, ~{N}-[5-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]-2-methyl-phenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide 著者 Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2019-08-01 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J.Med.Chem., 62, 2019
6SIB	Crystal structure of the domain-swapped N-lobe dimer of drosophila Arc 2 分子名称: Activity-regulated cytoskeleton associated protein 2 著者 Hallin, E.I, Kursula, P. 登録日 2019-08-09 公開日 2019-08-28 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. Plos One, 16, 2021
4XQ7	The crystal structure of the OAS-like domain (OLD) of human OASL 分子名称: 2'-5'-oligoadenylate synthase-like protein 著者 Ibsen, M.S, Gad, H.H, Andersen, L.L, Hornung, V, Julkunen, I, Sarkar, S.N, Hartmann, R. 登録日 2015-01-19 公開日 2015-04-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling. Nucleic Acids Res., 43, 2015
4Y07	Crystal structure of the HECT domain of human WWP2 分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2 著者 Gong, W, Li, J, Li, Z, Xu, Y. 登録日 2015-02-05 公開日 2015-11-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.507 Å) 主引用文献 Structure of the HECT domain of human WWP2 Acta Crystallogr.,Sect.F, 71, 2015
6B6U	Pyruvate Kinase M2 mutant - S437Y 分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Srivastava, D, Dey, M. 登録日 2017-10-03 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 56, 2017
4XVQ	H-Ras Y137E 分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Mattos, C. 登録日 2015-01-27 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.887 Å) 主引用文献 Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
6SJC	Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine 分子名称: 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, Aspartate--tRNA(Asp) ligase 著者 De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2019-08-13 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
1O7L	Molybdate-activated form of ModE from Escherichia coli 分子名称: CALCIUM ION, CHLORIDE ION, MOLYBDATE ION, ... 著者 Schuttelkopf, A.W, Hunter, W.N. 登録日 2002-11-08 公開日 2003-02-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal Structure of Activated Mode Reveals Conformational Changes Involving Both Oxyanion and DNA-Binding Domains J.Mol.Biol., 326, 2003
1O9H	rRNA methyltransferase aviRa from Streptomyces viridochromogenes at 2.4A 分子名称: RRNA METHYLTRANSFERASE 著者 Mosbacher, T.G, Schulz, G.E. 登録日 2002-12-13 公開日 2003-05-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes J.Mol.Biol., 329, 2003
1Q0V	Solution Structure of Tandem UIMs of Vps27 分子名称: hydrophilic protein; has cysteine rich putative zinc finger essential for function; Vps27p 著者 Swanson, K.A, Kang, R.S, Stamenova, S.D, Hicke, L, Radhakrishnan, I. 登録日 2003-07-17 公開日 2003-12-23 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation. Embo J., 22, 2003
4XVR	H-Ras Y137F 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Mattos, C. 登録日 2015-01-27 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.031 Å) 主引用文献 Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
6SFO	MAPK14 with bound inhibitor SR-318 分子名称: 5-azanyl-~{N}-[[4-(3-cyclohexylpropylcarbamoyl)phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, GLYCEROL, Mitogen-activated protein kinase 14, ... 著者 Schroeder, M, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2019-08-01 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 MAPK14 with bound inhibitor SR-318 To Be Published

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